Clinical Trials
60 articles on Clinical Trials, researched and written by the Shotlee Editorial Team from primary sources.
What's the Deal with Peptides? The Hyped Market Under FDA Review
An in-depth look at the FDA's review of unregulated peptide therapy, the safety concerns raised by experts, and the conflict between industry demand and clinical evidence.
8 min read
Eli Lilly's Retatrutide Shows Cardiovascular and Diabetic Benefits in Trials
Eli Lilly's investigational drug, retatrutide, has shown promising results in clinical trials, offering substantial weight loss and significant improvements in cardiovascular health and type 2 diabetes management.
7 min read
Peptides Get Their Regulatory Close-Up at FDA Review
The FDA is convening a panel to review regulations on popular injectable peptides. Learn about safety concerns, clinical evidence gaps, and what this means for patient access to peptide therapy.
8 min read
Thymosin Alpha-1 for Long COVID: FDA Concerns and Future Review
Thymosin alpha-1, a peptide with immune-modulating properties, is showing promise for Long COVID symptoms. However, the FDA has raised concerns about its compounding and stability, impacting its availability in the U.S. This article delves into the science, patient experiences, and regulatory landscape surrounding this peptide.
8 min read
Semaglutide for Weight Loss in Adults Over 65: New Study Findings
A recent analysis of the STEP trials reveals that semaglutide, the active ingredient in popular medications like Ozempic and Wegovy, offers significant weight loss and health benefits for adults over 65 with obesity, with a safety profile comparable to younger populations.
8 min read
Fat Jabs Slash Alcohol-Related Hospitalisations by More Than a Quarter
Recent analysis indicates that GLP-1 weight loss medications significantly reduce the risk of alcohol-related hospital admissions by approximately 26 percent compared to other diabetes treatments.
8 min read
The Peptides Bodybuilders and Gym Bros Are Using to Recover Faster After Exercise
An in-depth analysis of the peptides bodybuilders use for recovery, including TB-500 mechanisms, safety concerns, and current FDA regulatory standing.
8 min read
New “Trojan Horse” Drug Supercharges Weight Loss in Early Trials
A new hybrid molecule designed by Helmholtz Munich researchers acts as a Trojan horse to deliver metabolic compounds directly into cells, showing superior weight loss in mice compared to standard treatments.
8 min read
MOTS-C: A Peptide for Obesity Beyond GLP-1s?
While GLP-1 agonists have dominated weight loss discussions, a new peptide called MOTS-C is emerging with its own unique potential for tackling obesity and improving metabolic health. This article delves into what MOTS-C is, how it works, and its current research status.
7 min read
Melanotan II for Sunless Tan: What Young Men Are Experiencing
Young men are turning to Melanotan II for a sunless tan, but are experiencing unexpected and potentially dangerous side effects. This article delves into what the peptide is, its history, and the serious health concerns associated with its use.
8 min read
Why I Lost Virtually No Weight on Wegovy and Mounjaro
Explore the real-world experience of a patient who spent thousands on GLP-1 injections without significant results, and learn what worked instead.
7 min read
GP's Verdict on GLP-1 Tablet Rollout: A Damp Squib?
A UK GP shares his observations on the limited uptake of new GLP-1 weight loss tablets, suggesting patient familiarity with injections and daily dosing challenges may be factors.
8 min read
Study Links Hormonal Birth Control Use to Higher Likelihood of Needing Weight Loss Injections
A recent Danish study suggests that women who have used hormonal birth control may be more likely to seek weight loss injections such as Wegovy and Ozempic. This research sheds light on a long-reported, yet often unproven, connection between contraceptives and weight changes.
7 min read
Eli Lilly Prepares FDA Run for ‘Triple-G’ Weight Loss Drug With Phase 3 Data
Eli Lilly has announced positive Phase 3 results for retatrutide, positioning the triple-agonist drug for an FDA filing in 2027 with substantial weight loss outcomes.
7 min read
The Billion-Dollar Problem Limiting Access to Ozempic, Wegovy, and Zepbound
Despite clinical evidence highlighting the significant health benefits and cost-effectiveness of GLP-1 medications such as Ozempic, Wegovy, and Zepbound, many insurance plans continue to impose restrictions on patient access. This article delves into the financial and practical barriers, as well as the profound consequences for individuals seeking these transformative treatments.
7 min read
Oral GLP-1 Drugs May Quiet the Brain's Food Craving Circuit
New research suggests that oral GLP-1 medications, including those used for weight loss and diabetes, might work by influencing the brain's reward pathways, potentially reducing cravings for enjoyable foods and offering insights into treating substance use disorders.
8 min read
Katie Lee Biegel Shares Update on 'Incredibly Positive' GLP-1 Experience
Food Network personality Katie Lee Biegel opens up about her journey with GLP-1 medications, detailing her 'incredibly positive' experience with weight loss and enhanced well-being.
10 min read
Peptides, GLP-1s, and MAHA: A New Era in Wellness
The world of wellness is rapidly evolving, with groundbreaking advancements in peptide therapy and GLP-1 medications offering new avenues for health management and weight loss. This article delves into the science behind these innovations, explores the potential of 'MAHA' (Maximum Healthspan Aging), and discusses how individuals can navigate this exciting new frontier.
9 min read
Ozempic Face and Hair Loss: Evidence for GLP-1 Drug Side Effects
Weight-loss medications like Wegovy and Mounjaro have surged in popularity, leading to increased discussions about their side effects. This article delves into the scientific evidence for frequently reported concerns such as 'Ozempic face,' hair thinning, digestive problems, and eye conditions associated with GLP-1 agonists.
11 min read
Rosie O'Donnell: Mounjaro Changed My Life After Losing 30kg
Talk show host Rosie O'Donnell discusses her 30kg weight loss using Mounjaro, the subsequent skin concerns, and the mental health benefits of GLP-1 therapy.
6 min read
Novo Nordisk Sues Eli Lilly Over Which GLP-1 Sheds the Most Pounds
Novo Nordisk has filed a federal lawsuit against Eli Lilly, alleging deceptive advertising regarding the comparative weight loss efficacy of Zepbound and Wegovy. The dispute centers on dosage comparisons and clinical trial data interpretation.
8 min read
Eli Lilly to Seek FDA Approval for Obesity Drug Retatrutide
Eli Lilly announces plans to file for FDA approval of its triple-agonist obesity drug retatrutide in early 2027 following successful Phase 3 trial data.
8 min read
The New Drug Melting Body Fat From 38% To 22% — And The Side Effects Patients Are Ignoring
A detailed look at the case of Gary Anderton, who achieved significant weight loss using unregulated peptides, and the critical safety risks associated with this trend.
8 min read
AI Helps Stanford Scientists Discover Natural Ozempic Without the Usual Side Effects
Stanford Medicine researchers have identified a naturally occurring molecule that may suppress appetite and reduce body weight in a way that resembles semaglutide, the active ingredient in Ozempic.
8 min read
FDA to Review 7 Popular Peptides Touted for Weight Loss, Healing and Longevity
The FDA Pharmacy Compounding Advisory Committee is set to evaluate seven peptide substances currently available through the gray market. Experts weigh in on safety, efficacy, and future patient access.
7 min read
Novo Nordisk Sues Eli Lilly, Alleging Misleading Advertising of Obesity Drugs
Novo Nordisk has filed a lawsuit against Eli Lilly in New Jersey, claiming deceptive advertising regarding GLP-1 and dual-agonist weight loss medications.
7 min read
Semaglutide Telehealth: From The Access Boom To Regulatory Reckoning
The rapid rise of GLP-1 receptor agonists like semaglutide and tirzepatide has transformed obesity and diabetes care, generating billions in revenue for major manufacturers while creating unprecedented demand for weight management solutions. Telehealth platforms initially emerged as a critical access channel, offering convenient prescriptions and more affordable compounded versions during national shortages. Yet by 2025 and 2026, the sector faced a sharp pivot as FDA actions resolved shortages and curtailed large-scale compounding operations.
7 min read
The Workforce Runs on Weight Loss Drugs? Employees on GLP-1s Take Fewer Sick Days
A new study reveals significant reductions in long-term sick leave for workers taking GLP-1 medications, offering insights into workplace productivity and long-term health savings.
10 min read
US Regulators Consider Controversial Peptides Backed by RFK Jr.
The US Food and Drug Administration is evaluating the use of seven peptides, increasingly marketed for wellness and medical conditions. This review comes amidst soaring popularity, celebrity endorsements, and significant debate over their safety and efficacy.
8 min read
Ozempic Maker Novo Nordisk Sues Eli Lilly Over 'Materially Misleading' Ads
Novo Nordisk has filed a lawsuit against Eli Lilly, alleging deceptive advertising regarding weight-loss drugs. This legal battle highlights the intense competition between semaglutide and tirzepatide.
9 min read
Medicare's New GLP-1 Weight-Loss Drug Program: What to Know
Medicare is launching a new pilot program to increase access to GLP-1 medications for weight loss, offering a $50 monthly copay for eligible beneficiaries. This marks a significant step in covering obesity as a medical condition.
9 min read
Amy Schumer Shows Off Ongoing Weight Loss, Says C-Section Scar Makes Her a 'Warrior'
Comedian Amy Schumer discusses her 50-pound weight loss journey, Cushing syndrome diagnosis, and C-section recovery in a candid new update.
10 min read
Which GLP-1 Works Best? New Meta-Study Puts Medications Head-to-Head
A comprehensive meta-analysis from the University of Georgia compares three major GLP-1 medications. Discover which drug offers the highest weight loss efficacy and what the data means for patients.
8 min read
What is the viral 'natural Ozempic' drink?
A viral trend promoting a 'natural Ozempic' drink made with gelatin and water is circulating on social media. This article delves into what the drink is, its purported benefits, and the expert opinions on its role in weight management.
6 min read
The Overlooked Nutrition Risks of Ozempic and Wegovy
New research from UCL and Cambridge highlights critical nutrition gaps in GLP-1 therapy. Discover the risks of muscle loss and deficiencies, and how to manage them safely.
8 min read
Popular Weight-Loss Drugs Ozempic and Wegovy May Slow Biological Aging
A new clinical trial suggests that semaglutide, the active ingredient in Ozempic and Wegovy, may help slow biological processes associated with aging in adults with HIV.
8 min read
Ozempic and Similar Weight-Loss Medications Linked to 30% Lower Breast Cancer Risk
A major study from Penn Medicine reveals a potential link between GLP-1 medications like Ozempic and a significant reduction in breast cancer risk, offering new hope for preventive care.
7 min read
GLP-1 Weight-Loss Drugs Linked to Lower Risks of Addiction and Overdose
Explore the groundbreaking research linking GLP-1 medications, including Ozempic, Wegovy, Mounjaro, and Zepbound, to a reduced risk of substance use disorders and fewer addiction-related emergencies.
8 min read
New Weight Loss Pill Beats Oral Ozempic in Major Clinical Trial
A recent Phase 3 clinical trial indicates that orforglipron offers superior blood sugar control and weight loss compared to oral semaglutide, though side effects remain a consideration.
9 min read
Bariatric Surgery Shows 5x More Weight Loss Than GLP-1s in Real-World Study
A groundbreaking real-world comparison study presented at the ASMBS 2025 Annual Scientific Meeting found that bariatric surgery resulted in approximately five times more weight loss compared to popular GLP-1 receptor agonist medications over a two-year period. This research highlights important considerations for patients and healthcare providers navigating weight management options.
7 min read
The Next Ozempic: A 4-in-1 Breakthrough for Lasting Weight Loss
While Ozempic and similar GLP-1 agonists have revolutionized weight management, new research from Tufts University is exploring a novel 4-in-1 peptide that targets four hormone receptors for potentially greater efficacy and fewer side effects, moving closer to the gold standard of bariatric surgery.
6 min read
Novo Nordisk's Semaglutide Implant Could Replace Ozempic Injections
Novo Nordisk and Vivani Medical are developing a semaglutide implant that could eliminate the need for weekly injections. Here is everything to know about the technology.
6 min read
Beyond the Pen: Navigating Weight Loss & Societal Pressures with GLP-1s
Discover how GLP-1 medications are transforming lives, offering significant weight loss and improved self-esteem. This article delves into the personal victories and the broader societal implications, including the persistent pressures on women's bodies.
8 min read
Beyond Ozempic: A Dark Twist on Weight Loss Obsession
The rise of GLP-1 agonists has sparked a global conversation about weight loss. This article delves into the cultural phenomenon, its psychological underpinnings, and how a new horror film, 'Saccharine,' offers a chilling commentary.
7 min read
Beyond the Hype: Understanding Peptides for Weight Loss and Health
Curious about peptides and their role in weight loss, cholesterol management, and overall health? This article breaks down what peptides are, how they work, and what the science says about popular options like GLP-1 agonists.
7 min read
Beyond the Hype: Understanding GLP-1s and Weight Management
The rise of GLP-1 medications has revolutionized weight management. This comprehensive guide delves into semaglutide, tirzepatide, and other peptide therapies, offering insights into their efficacy, potential side effects, and how to track your progress effectively.
7 min read
Ozempic vs. Jardiance: Better Heart Protection for Diabetics with AFib
A new study compares GLP-1 and SGLT-2 inhibitors in patients with type 2 diabetes and atrial fibrillation, revealing significant differences in heart health outcomes.
7 min read
Ozempic, Wegovy, Mounjaro: The GLP-1 Revolution in Weight Loss
A closer look at the groundbreaking GLP-1 medications, including Ozempic, Wegovy, and Mounjaro, and their transformative effects on weight management and overall health.
6 min read
Illegal Peptide Shots in Brazil: The Hidden Risks for Expats
Foreign residents in Brazil face a growing grey market of unregulated injectable peptides. Here is what the health regulator Anvisa says about safety and legality.
7 min read
Peptides and Health: The Truth Behind the Beauty and Weight Loss Claims
Peptides are the newest buzzword in health and beauty, promising everything from wrinkle reduction to profound weight loss. But does the science actually back up the claims, and are they safe?
7 min read
Tirzepatide vs. Semaglutide: Which Weight Loss Peptide Reigns Supreme?
The landscape of medical weight loss has been revolutionized by potent peptide therapies. Among the most talked-about are semaglutide and tirzepatide, the active ingredients in popular medications like Wegovy, Ozempic, Zepbound, and Mounjaro. But when it comes to shedding pounds, which one truly takes the lead? This article delves into the science, the studies, and the practical differences to help you understand their comparative effectiveness.
7 min read
Beyond GLP-1s: Understanding the Peptide Therapy Health Craze
Peptide therapy is rapidly gaining traction far beyond the well-known GLP-1 medications. This deep dive explores the science, the 'health-maxing' movement, supply chain complexities, and the crucial regulatory landscape shaping the future of these powerful compounds.
7 min read
Wegovy Arrives in Jordan: A New Era for Weight Management
Novo Nordisk has officially launched Wegovy®️ (semaglutide 2.4 mg) in Jordan, marking a significant advancement in the country's approach to tackling the growing challenge of excess weight and its associated health risks.
7 min read
Wegovy & Mounjaro: Navigating Medicare's New Path to Weight Loss
For years, Medicare's stance on GLP-1 medications for weight loss was a firm 'no.' However, a significant shift is underway. Discover how the new 'Bridge' program opens doors to crucial weight management tools like Wegovy and Mounjaro, and what you need to know.
6 min read
Beyond the Hype: Understanding the 'Natural Ozempic' Gelatin Trend
A viral trend promoting a 'natural Ozempic' drink made with gelatin and water is sweeping social media. But does it live up to the hype? We explore the science behind this appetite suppressant and what health experts say about its effectiveness and safety.
6 min read
Ozempic Culture: Why Medical Weight Loss Needs Better Guardrails
As semaglutide medications become ubiquitous, we must balance their life-saving cardiovascular benefits with the dangers of normalizing extreme thinness and disordered eating behaviors.
7 min read
Ozempic, Wegovy, Mounjaro: Your Health Journey & What to Track
The rise of GLP-1 medications like Ozempic, Wegovy, and Mounjaro has revolutionized weight management and metabolic health for millions. But beyond the prescription, embarking on this journey requires mindful tracking of your progress, symptoms, and overall well-being. This guide explores what you should be paying attention to, offering practical insights for both patients and the natural health industry.
7 min read
Unlock Your Body's Fat-Burning Hormone: The Fiber Secret
You've likely heard of GLP-1 medications like Ozempic and Wegovy. But did you know your body naturally produces this powerful hormone every time you eat? The key to maximizing your body's own GLP-1 lies in a specific type of dietary fiber. This article dives into the science behind it and reveals the top foods that can help you tap into your body's natural appetite-regulating system.
7 min read
Beyond Ozempic: Exploring the Expanding World of Peptide Therapeutics
Peptides are making waves in health and wellness, driven by the success of medications like Ozempic. This article delves into what peptides are, their growing applications, and the exciting future of peptide therapy.
8 min read
Zepbound vs. Wegovy: New Meta-Analysis Reveals Top Weight Loss Drug
A comprehensive meta-analysis from the University of Georgia has finally put major weight loss medications head-to-head. Here is what the data says about Zepbound, Wegovy, and Saxenda.
8 min read