Longevity Peptides Guide
Epithalon, Thymosin Alpha-1
Complete guide to longevity peptides — Epithalon, Thymosin Alpha-1, MOTS-c, Elamipretide, FOXO4-DRI, and 5-Amino-1MQ.
Thymic Peptides
Epithalon
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. It is best known for its ability to activate telomerase — the enzyme responsible for extendin
Thymosin Alpha-1 (TA1)
Thymosin Alpha-1 is a 28 amino acid peptide naturally secreted by the thymus gland. It is a potent immune modulator with decades of clinical use in chronic viral infections and cancer adjunct therapy.
Mitochondrial Peptides
MOTS-c
MOTS-c is remarkable because it is encoded by mitochondrial DNA — one of only a handful of peptides with this origin. It activates AMPK (AMP-activated protein kinase), the master metabolic regulator.
Elamipretide (SS-31)
Elamipretide (also called SS-31 or MTP-131) is a mitochondria-targeted peptide that stabilizes cardiolipin in the inner mitochondrial membrane — critical for maintaining the electron transport chain.
Senolytics & Metabolic Longevity Compounds
FOXO4-DRI
A D-retro inverso peptide that disrupts FOXO4-p53 interaction in senescent "zombie" cells, triggering selective apoptosis.
Dasatinib + Quercetin
The most studied senolytic combination in human trials. Dasatinib (tyrosine kinase inhibitor) + Quercetin (flavonoid) clear senescent cells via complementary pathways.
5-Amino-1MQ
A small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that raises intracellular NAD+ levels and activates sirtuins for metabolic enhancement.
Vital Protocol FAQs
How often should I cycle Epithalon?
The most common Epithalon protocol is a 10-day cycle administered twice per year. Each cycle typically involves daily injections of 5-10mg for 10 consecutive days. Spacing cycles 6 months apart is the
What biomarkers should I track on a longevity peptide protocol?
Key biomarkers include epigenetic age (TruAge or similar methylation tests), telomere length (SpectraCell or Life Length), inflammatory markers (IL-6, hsCRP), IGF-1, fasting insulin, testosterone/DHEA
What is the difference between FOXO4-DRI and other senolytics?
FOXO4-DRI is a peptide-based senolytic that disrupts the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis specifically in "zombie cells." Unlike small-molecule senolytics suc
Guide FAQs
Complete guide to longevity peptides — Epithalon, Thymosin Alpha-1, MOTS-c, Elamipretide, FOXO4-DRI, and 5-Amino-1MQ.
Yes. Shotlee supports tracking Longevity Peptides doses, side effects, and health metrics. It is free to use.
References
- [1]Clinical TrialKhavinson VK et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592.
- [2]Clinical TrialLee C et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metab. 2015;21(3):443-454.
- [3]Clinical TrialBaar MP et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017;169(1):132-147.
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