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📖Complete Guide✅Updated 2026🔬Evidence-Based

Longevity Peptides Guide

Epithalon, Thymosin Alpha-1

Complete guide to longevity peptides — Epithalon, Thymosin Alpha-1, MOTS-c, Elamipretide, FOXO4-DRI, and 5-Amino-1MQ.

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Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
Longevity PeptidesB12
LONGEVITY PEPTIDES
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Longevity Peptides
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Level Predictor
Estimated serum level & future decay
~5 days
Half-Life
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
● Today
ACTIVE MEDICATIONS
Longevity PeptidesRetatrutide
TODAY5.42 mgFeb 14Feb 22Mar 14
0mg2.7mg5.42mg (Peak)
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
Longevity PeptidesB12
LONGEVITY PEPTIDES
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Longevity Peptides
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Level Predictor
Estimated serum level & future decay
~5 days
Half-Life
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
● Today
ACTIVE MEDICATIONS
Longevity PeptidesRetatrutide
TODAY5.42 mgFeb 14Feb 22Mar 14
0mg2.7mg5.42mg (Peak)
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01WHAT TO TRACK

Thymic Peptides

01
🔬
Epithalon
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. It is best known for its ability to activate telomerase — the enzyme responsible for extendin
02
🔬
Thymosin Alpha-1 (TA1)
Thymosin Alpha-1 is a 28 amino acid peptide naturally secreted by the thymus gland. It is a potent immune modulator with decades of clinical use in chronic viral infections and cancer adjunct therapy.
02WHAT TO TRACK

Mitochondrial Peptides

01
🔬
MOTS-c
MOTS-c is remarkable because it is encoded by mitochondrial DNA — one of only a handful of peptides with this origin. It activates AMPK (AMP-activated protein kinase), the master metabolic regulator.
02
🔬
Elamipretide (SS-31)
Elamipretide (also called SS-31 or MTP-131) is a mitochondria-targeted peptide that stabilizes cardiolipin in the inner mitochondrial membrane — critical for maintaining the electron transport chain.
03WHAT TO TRACK

Senolytics & Metabolic Longevity Compounds

01
🔬
FOXO4-DRI
A D-retro inverso peptide that disrupts FOXO4-p53 interaction in senescent "zombie" cells, triggering selective apoptosis.
02
🔬
Dasatinib + Quercetin
The most studied senolytic combination in human trials. Dasatinib (tyrosine kinase inhibitor) + Quercetin (flavonoid) clear senescent cells via complementary pathways.
03
🔬
5-Amino-1MQ
A small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that raises intracellular NAD+ levels and activates sirtuins for metabolic enhancement.
04WHAT TO TRACK

Vital Protocol FAQs

01
🧬
How often should I cycle Epithalon?
The most common Epithalon protocol is a 10-day cycle administered twice per year. Each cycle typically involves daily injections of 5-10mg for 10 consecutive days. Spacing cycles 6 months apart is the
02
📱
What biomarkers should I track on a longevity peptide protocol?
Key biomarkers include epigenetic age (TruAge or similar methylation tests), telomere length (SpectraCell or Life Length), inflammatory markers (IL-6, hsCRP), IGF-1, fasting insulin, testosterone/DHEA
03
🔬
What is the difference between FOXO4-DRI and other senolytics?
FOXO4-DRI is a peptide-based senolytic that disrupts the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis specifically in "zombie cells." Unlike small-molecule senolytics suc
05FAQ

Guide FAQs

Complete guide to longevity peptides — Epithalon, Thymosin Alpha-1, MOTS-c, Elamipretide, FOXO4-DRI, and 5-Amino-1MQ.

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📚References & sources

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