What is MOTS-c?

MOTS-c is one of the most exciting discoveries in longevity peptide research. Unlike most peptides encoded in the nuclear genome, MOTS-c is encoded in mitochondrial DNA โ€” the genome within the cellular powerhouse. It acts as a signaling molecule that travels from mitochondria to the nucleus and even into circulation.

Its primary mechanism is activation of AMPK (AMP-activated protein kinase), which increases glucose uptake independent of insulin, enhances fatty acid oxidation, improves mitochondrial efficiency, and reduces oxidative stress. Studies have shown it can reverse age-related declines in physical performance and metabolism in aged mice.

MOTS-c is a research peptide and is not FDA-approved for human use. It is typically sourced through research chemical suppliers and administered via subcutaneous injection. Always consult a healthcare provider and source from reputable, lab-tested suppliers.

FAQ

What is MOTS-c?

A mitochondria-derived peptide that activates AMPK, improving glucose metabolism, fat oxidation, and physical performance. Described as an "exercise mimetic" for its metabolic effects without physical activity.

What is the typical MOTS-c protocol?

5โ€“10mg subcutaneously 3โ€“5 times per week, or daily. Must be injected โ€” oral bioavailability is very low. Many stack with BPC-157 or other longevity peptides.

How do I track MOTS-c with Shotlee?

Log each injection with dose, injection site, and time. Track energy levels, exercise performance, and any subjective metabolic changes. Shotlee lets you run multiple peptide protocols simultaneously.

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