FOXO4-DRI Tracker
Track the Senolytic Peptide — Clear Zombie Cells
FOXO4-DRI selectively induces apoptosis in senescent cells — the "zombie cells" that accumulate with aging and drive chronic inflammation. Track your senolytic protocol doses, cycles, and biomarkers with Shotlee.
What is FOXO4-DRI?
FOXO4-DRI is a synthetic retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells. Normally, FOXO4 sequesters p53 in the nucleus, preventing senescent cells from undergoing apoptosis and turning them into chronic inflammation factories (secreting SASP — Senescence Associated Secretory Phenotype).
FOXO4-DRI competes with endogenous FOXO4, freeing p53 to trigger apoptosis specifically in senescent cells while leaving healthy cells unaffected. Published research from Van Deursen's group (Nature Medicine, 2017) showed dramatic restoration of physical function, fur density, and organ health in fast-aged mice.
Highly experimental research compound. No clinical trials in humans have been completed. Use only with experienced physician oversight and comprehensive baseline bloodwork. The risk-benefit profile for human use is not yet established.
FAQ
What is FOXO4-DRI?
A senolytic peptide that frees p53 in senescent cells to trigger their programmed death (apoptosis). Mouse studies showed remarkable restoration of physical function and organ health. No completed human clinical trials.
What protocol do biohackers use?
Protocols vary: 5–10mg subcutaneously 1–3x/week in intermittent cycles. Based on mouse studies of 5mg/kg 3x/week intraperitoneally. Human dosing is highly experimental — requires physician supervision.
What should I track?
Inflammatory markers (IL-6, CRP), physical performance, energy levels, and subjective recovery. Shotlee logs dose, timing, cycle structure, and lets you correlate with any lab values.