What is Elamipretide?

Elamipretide (SS-31, Bendavia) is a small tetrapeptide (H-D-Arg-Dmt-Lys-Phe-NH2) that selectively accumulates in the inner mitochondrial membrane — specifically at cardiolipin, a phospholipid unique to mitochondria. Cardiolipin is essential for maintaining cristae structure and supporting the electron transport chain complexes that produce ATP.

By stabilizing cardiolipin, elamipretide helps restore mitochondrial membrane potential, reduce reactive oxygen species generation, and improve overall mitochondrial bioenergetics. It has been studied in heart failure (HFrEF, HFpEF), mitochondrial myopathy, Barth syndrome, and ischemia-reperfusion injury.

In the longevity community, elamipretide is valued for its highly targeted mitochondrial mechanism — unlike general antioxidants, it works at the specific site where age-related mitochondrial dysfunction originates. Research compound; not FDA-approved for longevity use.

FAQ

What is elamipretide (SS-31)?

A mitochondria-targeting peptide that stabilizes cardiolipin to improve inner mitochondrial membrane integrity and electron transport efficiency. Studied for heart failure, mitochondrial disease, and longevity.

What is the typical protocol?

Clinical trials use 0.025–0.25mg/kg/day subcutaneously. Off-label longevity use typically involves 5–10mg/day SQ. Always under medical supervision.

How do I track it on Shotlee?

Log each injection with dose and time. Track energy levels, exercise performance, and any cardiac function markers your physician monitors. Consistent logging over 4–12 weeks reveals your personal response.

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