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From Oprah to Elon Musk, Stars Who Suffered 'Ozempic Face' Due to Intense GLP-1 Weight Reduction - Featured image
Health & Wellness

From Oprah to Elon Musk, Stars Who Suffered 'Ozempic Face' Due to Intense GLP-1 Weight Reduction

Dr. Adrian Vale, MD
Reviewed by Dr. Adrian Vale, MDInternal Medicine · Board-Certified Obesity Medicine
·January 1, 2026·3 min read

On this page

  • The Rise of the Ozempic Phenomenon and 'Ozempic Face'
  • Beyond Celebrities: Widespread Use of GLP-1 Drugs
  • Celebrities Affected by the Transformation

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The trend of using GLP-1 medications like Ozempic for weight loss has led to a phenomenon known as 'Ozempic face,' marked by sunken eyes and defined facial features. Celebrities and regular individuals alike have embraced these drugs, with over 10% of Americans reportedly using them in 2025. From Oprah to Elon Musk, several high-profile figures have experienced noticeable changes in their appearances.

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On this page

  • The Rise of the Ozempic Phenomenon and 'Ozempic Face'
  • Beyond Celebrities: Widespread Use of GLP-1 Drugs
  • Celebrities Affected by the Transformation

The Rise of the Ozempic Phenomenon and 'Ozempic Face'

A genuine wave of enthusiasm for Ozempic is sweeping through, with numerous top-tier celebrities participating, whether they are performers, vocalists, or industry innovators. As the adoption of GLP-1 drugs for shedding pounds grows, a fresh expression has surfaced: 'Ozempic face.' This isn't an official medical designation; instead, it illustrates the profound alterations in someone's facial look following their involvement in the Ozempic movement.

The GLP-1 medication doesn't merely eliminate weight from the body but also triggers significant shifts in facial contours. Individuals who have employed Ozempic for weight reduction frequently observe that their eyes appear more hollow, creases become subtler, lips seem slimmer, and the general skeletal framework of the face becomes sharper.

Beyond Celebrities: Widespread Use of GLP-1 Drugs

Yet, it's not solely famous people; ordinary folks have started incorporating GLP-1 treatments such as Ozempic, Wegovy, and Mounjaro into their routines to slim down. Several prominent personalities have even publicly disclosed their reliance on them within their exercise programs, fueling the medications' commercial success. A survey conducted by KFF Health Tracking indicated that in 2025, more than 10% of U.S. residents reported utilizing some form of GLP-1.

Celebrities Affected by the Transformation

Let's examine the well-known individuals who sought assistance from GLP-1 drugs, resulting in striking changes to their visages. Starting with Oprah Winfrey, she candidly acknowledged relying on a weight-reduction injection. In 2023, she shared with PEOPLE how the shot aided in managing 'food noise.' Although natural maturation has influenced her appearance, professionals suggest the weight-loss injection may have had a more substantial impact.

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Elon Musk stands out as another major figure who has openly discussed using a GLP-1 treatment. He posted on Twitter in November 2022: 'Fasting + Ozempic/Wegovy + No tasty food near me.' Specialists argue, however, that the tech entrepreneur has also encountered 'Ozempic face.' Previously, his countenance seemed plumper, but it has now become considerably more angular.

Meghan Trainor has been straightforward about incorporating some GLP-1 medication to regain her form post the arrival of her eldest child. Even though she mentioned taking a reduced dosage alongside her spouse, Daryl Sabara, the shifts are quite evident. Her facial traits now exhibit enhanced clarity, and her laugh lines have deepened.

Additionally, Scott Disick was speculated to be employing GLP-1 after a February 2025 installment of The Kardashians. A peek into his fridge showed Mounjaro use, which the TV personality confirmed. 'By the way, I'm not ashamed that I took it!' he declared. Nonetheless, online observers expressed worry, noting his 'Ozempic face' appeared excessively severe, with notably hollow eyes.

Health tracking apps like Shotlee can assist in monitoring these bodily changes during weight loss journeys.

Source Information

Originally published by The Inquisitr.Read the original article →

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Dr. Adrian Vale, MD — Internal Medicine · Board-Certified Obesity Medicine
Medically reviewed

Dr. Adrian Vale, MD

Internal Medicine · Board-Certified Obesity Medicine

Dr. Adrian Vale is a board-certified internal medicine physician with a clinical focus on obesity medicine and metabolic health. He reviews Shotlee guides and articles on GLP-1 medications, peptide therapy, and weight-management protocols for clinical accuracy.

View all articles reviewed by Dr. Adrian Vale, MD
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