长寿多肽指南
Epithalon, Thymosin Alpha-1
长寿多肽完整指南——深入解析 Epithalon、Thymosin Alpha-1、MOTS-c、Elamipretide、FOXO4-DRI 和 5-Amino-1MQ。
胸腺多肽
Epithalon
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. It is best known for its ability to activate telomerase — the enzyme responsible for extendin
Thymosin Alpha-1 (TA1)
Thymosin Alpha-1 is a 28 amino acid peptide naturally secreted by the thymus gland. It is a potent immune modulator with decades of clinical use in chronic viral infections and cancer adjunct therapy.
线粒体多肽
MOTS-c
MOTS-c is remarkable because it is encoded by mitochondrial DNA — one of only a handful of peptides with this origin. It activates AMPK (AMP-activated protein kinase), the master metabolic regulator.
Elamipretide (SS-31)
Elamipretide (also called SS-31 or MTP-131) is a mitochondria-targeted peptide that stabilizes cardiolipin in the inner mitochondrial membrane — critical for maintaining the electron transport chain.
衰老细胞清除与代谢长寿化合物
FOXO4-DRI
A D-retro inverso peptide that disrupts FOXO4-p53 interaction in senescent "zombie" cells, triggering selective apoptosis.
Dasatinib + Quercetin
The most studied senolytic combination in human trials. Dasatinib (tyrosine kinase inhibitor) + Quercetin (flavonoid) clear senescent cells via complementary pathways.
5-Amino-1MQ
A small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that raises intracellular NAD+ levels and activates sirtuins for metabolic enhancement.
核心方案常见问题
How often should I cycle Epithalon?
The most common Epithalon protocol is a 10-day cycle administered twice per year. Each cycle typically involves daily injections of 5-10mg for 10 consecutive days. Spacing cycles 6 months apart is the
What biomarkers should I track on a longevity peptide protocol?
Key biomarkers include epigenetic age (TruAge or similar methylation tests), telomere length (SpectraCell or Life Length), inflammatory markers (IL-6, hsCRP), IGF-1, fasting insulin, testosterone/DHEA
What is the difference between FOXO4-DRI and other senolytics?
FOXO4-DRI is a peptide-based senolytic that disrupts the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis specifically in "zombie cells." Unlike small-molecule senolytics suc
指南常见问题
长寿多肽是一类旨在延缓衰老过程的化合物，本指南涵盖了 Epithalon、Thymosin Alpha-1、MOTS-c、Elamipretide、FOXO4-DRI 和 5-Amino-1MQ 等核心品种。
可以。Shotlee 支持追踪长寿多肽的剂量、副作用和健康指标。该应用可免费使用。
参考文献
- [1]Clinical TrialKhavinson VK et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592.
- [2]Clinical TrialLee C et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metab. 2015;21(3):443-454.
- [3]Clinical TrialBaar MP et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017;169(1):132-147.