What is LL-37?

LL-37 is the active fragment of human cathelicidin (hCAP18) โ€” the only cathelicidin peptide humans produce. It is produced by neutrophils, epithelial cells, and macrophages in response to infection and inflammation. Its name comes from its structure: 37 amino acids beginning with two leucines (LL).

LL-37 kills bacteria by inserting into and disrupting microbial cell membranes through an electrostatic mechanism that preferentially targets bacterial over mammalian membranes. Beyond direct antimicrobial action, it modulates TLR (Toll-like receptor) signaling, recruits immune cells, promotes angiogenesis, and plays a key role in wound healing and epithelial barrier repair.

Research peptide; not FDA-approved for off-label use. Used by physicians in functional medicine for immune optimization, wound healing protocols, and anti-inflammatory applications. Dose-sensitive โ€” must be used with medical supervision.

FAQ

What is LL-37?

The only human cathelicidin peptide โ€” both antimicrobial (disrupts bacterial membranes) and immunomodulatory (modulates TLR signaling, recruits immune cells). Studied for infection, inflammation, wound healing, and skin conditions like rosacea.

What are common use cases?

Chronic wound healing, respiratory infection support, anti-inflammatory protocols, rosacea research, and immune optimization. Research compound โ€” requires physician supervision.

How do I track it?

Log each injection with dose and time. Track inflammation markers, skin changes, energy, and illness frequency. Shotlee lets you correlate all of these with your dosing schedule.

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