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📖Complete Guide✅Updated 2026🔬Evidence-Based

LL-37 Guide (2026)

Complete Guide & Evidence (2026)

Human cathelicidin antimicrobial peptide — part of the innate immune system. Antiviral, antibiofilm, wound healing.

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Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
LL-37B12
LL-37
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
LL-37
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
LL-37Retatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
LL-37B12
LL-37
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
LL-37
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
LL-37Retatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01WHAT TO TRACK

How LL-37 Works

01
🔬
Antimicrobial Action
Disrupts bacterial cell membranes directly. Kills gram-positive and gram-negative bacteria. Active against drug-resistant strains (MRSA)
02
🔬
Biofilm Disruption
Penetrates and dismantles bacterial biofilms. Enhances antibiotic penetration. Key for chronic Lyme and SIBO protocols
03
🛡️
Immune Modulation
Activates innate immune cells. Antiviral: inhibits influenza, HIV, SARS-CoV-2. Promotes wound healing and angiogenesis
02BACKGROUND

Key Research Data

Daily subcutaneous dose used in most reported research protocols.

Reduction in P. aeruginosa biofilm biomass at physiologic LL-37 concentrations.

Active against influenza A/B, RSV, HIV, HSV, and multiple other viral families.

03DEEP DIVE

LL-37 Protocol Overview

Timing: Morning administration is typically preferred due to immune activation. Many practitioners stack LL-37 with BPC-157 or thymosin alpha-1 for synergistic immune modulation.

04WHAT TO TRACK

Side Effects & Considerations

01
⚠️
Common Side Effects
Immune activation response (flu-like, 1–3 days). Injection site redness or warmth. Herxheimer-like reaction with pathogen die-off
02
🔬
Cautions
Avoid in active autoimmune flares without guidance. High doses may overstimulate immune system. Monitor inflammatory markers during long cycles
05WHAT TO TRACK

Vital Protocol FAQs

01
🔬
What is LL-37 peptide?
LL-37 is the only member of the cathelicidin family of antimicrobial peptides expressed in humans. It is part of the innate immune system, secreted by neutrophils, epithelial cells, and macrophages in
02
💉
What dose of LL-37 is used in research protocols?
Research protocols most commonly report 50–100 mcg/day subcutaneously, typically taken in the morning due to its immune-activating properties. Some aggressive immune-support protocols use up to 200 mc
03
🔬
Who uses LL-37 peptide?
LL-37 is primarily used by people dealing with chronic infections, biotoxin illness (mold/Lyme), recurrent respiratory infections, and biofilm-related conditions. Some researchers are investigating it
04
⚠️
What are the side effects of LL-37?
The most commonly reported side effect is a strong immune activation response — fatigue, flu-like feelings, or warmth in the first 1–3 days as the immune system upregulates. Injection site reactions a
06FAQ

Guide FAQs

Human cathelicidin antimicrobial peptide — part of the innate immune system. Antiviral, antibiofilm, wound healing.

Yes. Shotlee supports tracking LL-37 doses, side effects, and health metrics. It is free to use.

Free · Always

Track Your LL-37 Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

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📚References & sources

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