KPV Tracker
Track the Anti-Inflammatory Gut Health Tripeptide
KPV (Lys-Pro-Val) is a tripeptide derived from alpha-MSH with potent gut anti-inflammatory effects. Track daily doses, gut symptoms, inflammation markers, and IBD response with Shotlee.
What is KPV?
KPV is a tripeptide (lysine-proline-valine) representing the final three amino acids of alpha-melanocyte stimulating hormone (α-MSH). While α-MSH itself has broad immunomodulatory and melanogenic effects, KPV retains the anti-inflammatory activity in a much smaller, more stable molecule.
KPV works primarily through inhibition of NF-κB (nuclear factor kappa B), a master regulator of inflammatory gene expression. This reduces production of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α. In the gut, it also directly protects intestinal epithelial cells and reduces immune cell infiltration in inflamed tissue.
Oral KPV is particularly relevant because it survives gastrointestinal passage relatively intact due to its small size and resistant structure, making it effective for gut-focused applications without injection. Research compound; use under physician guidance.
FAQ
What is KPV?
A tripeptide (Lys-Pro-Val) from the C-terminus of alpha-MSH. Potent gut anti-inflammatory: inhibits NF-κB, reduces IL-6 and TNF-alpha, protects intestinal epithelial cells. Studied for IBD, colitis, and gut inflammation.
How is it taken?
0.5–1mg orally daily or twice daily (survives gut digestion well). Subcutaneous 0.5–2mg/day also used. Topical formulations exist for skin inflammation. Research compound — physician guidance required.
How do I track KPV on Shotlee?
Log each dose with amount, route (oral/SQ), and time. Track gut symptoms (pain, bloating, bowel movements), inflammation markers, and overall wellbeing. Great for correlating dose timing with symptom changes.