Compounded Semaglutide Guide
Safety, Dosing & Pharmacies
Complete guide to compounded semaglutide. Learn about safety, how to find reputable pharmacies, dosing, and what to watch out.
What Is Compounded Semaglutide?
Compounded semaglutide is the same active molecule as Ozempic and Wegovy, but prepared by licensed compounding pharmacies rather than Novo Nordisk.
Why it exists: The FDA allows compounding during drug shortages. Since Ozempic and Wegovy have been on the shortage list, compounding pharmacies can legally produce semaglutide.
Key difference: Compounded medications are NOT FDA-approved. They don't undergo the same testing and quality control as brand-name drugs. Quality depends entirely on the pharmacy.
503A vs 503B Pharmacies
State-regulated (less oversight)
Compounds on individual prescription basis
May or may not have third-party testing
Generally less consistent quality
More common, lower prices
FDA-registered (stricter oversight)
Can compound in bulk batches
Required to follow cGMP (Current Good Manufacturing Practice)
More consistent quality control
Slightly higher prices, safer choice
Understanding Compounded Dosing
Compounded semaglutide typically comes in vials with a concentration (e.g., 2.5mg/mL or 5mg/mL). You'll draw up your dose using insulin syringes.
Example: From a 2.5mg/mL vial, to get 0.25mg dose, draw up 10 units (0.1mL). For 0.5mg, draw 20 units (0.2mL). For 1.0mg, draw 40 units (0.4mL).
Tip: Use Shotlee's peptide reconstitution calculator to verify your dosing calculations and track your vial usage.
Guide FAQs
Complete guide to compounded semaglutide. Learn about safety, how to find reputable pharmacies, dosing, and what to watch out.
Yes. Shotlee supports tracking Compounded Semaglutide doses, side effects, and health metrics. It is free to use.
References
- [1]FDAFDA Office of Regulatory Affairs. FDA warns consumers not to use compounded semaglutide or tirzepatide. U.S. Food and Drug Administration. 2024.
- [2]Clinical TrialWilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002.
- [3]FDANovo Nordisk. Ozempic (semaglutide) Prescribing Information. U.S. Food and Drug Administration.
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