Compounded Semaglutide
Everything You Need to Know
Compounded semaglutide costs a fraction of Ozempic or Wegovy. Here's how to use it safely, find reputable pharmacies, and understand the risks.
What Is Compounded Semaglutide?
Compounded semaglutide is the same active molecule as Ozempic and Wegovy, but prepared by licensed compounding pharmacies rather than Novo Nordisk.
Why it exists: The FDA allows compounding during drug shortages. Since Ozempic and Wegovy have been on the shortage list, compounding pharmacies can legally produce semaglutide.
Key difference: Compounded medications are NOT FDA-approved. They don't undergo the same testing and quality control as brand-name drugs. Quality depends entirely on the pharmacy.
503A vs 503B Pharmacies
- • State-regulated (less oversight)
- • Compounds on individual prescription basis
- • May or may not have third-party testing
- • Generally less consistent quality
- • More common, lower prices
- • FDA-registered (stricter oversight)
- • Can compound in bulk batches
- • Required to follow cGMP (Current Good Manufacturing Practice)
- • More consistent quality control
- • Slightly higher prices, safer choice
Recommendation: If possible, use a 503B pharmacy for better quality assurance.
Red Flags to Avoid
No Prescription Required
Legitimate compounding always requires a valid prescription from a licensed provider.
Too Cheap ($50-100/month)
If it seems too good to be true, it probably is. Quality semaglutide costs money to produce.
No COA (Certificate of Analysis)
Reputable pharmacies provide third-party testing showing purity and potency.
Ships from Overseas
Compounded medications should come from US-based pharmacies. International sources are risky.
Understanding Compounded Dosing
Compounded semaglutide typically comes in vials with a concentration (e.g., 2.5mg/mL or 5mg/mL). You'll draw up your dose using insulin syringes.
Example: From a 2.5mg/mL vial, to get 0.25mg dose, draw up 10 units (0.1mL). For 0.5mg, draw 20 units (0.2mL). For 1.0mg, draw 40 units (0.4mL).
Tip: Use Shotlee's peptide reconstitution calculator to verify your dosing calculations and track your vial usage.
FAQ
Is compounded semaglutide as effective as Ozempic?
If properly formulated, yes—it's the same molecule. However, quality varies. Inconsistent potency means you might not get the expected effect.
Will compounded semaglutide always be available?
No. Once Wegovy/Ozempic shortages resolve, the FDA may prohibit compounding. This could happen with little notice.
How should I store compounded semaglutide?
Refrigerate unopened vials (36-46°F). Once opened, most pharmacies recommend use within 28-30 days. Never freeze.
Track Your Compounded Medication
Use Shotlee to track vials, calculate doses, and monitor your progress on compounded semaglutide.
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