Semaglutide vs Liraglutide

Head-to-Head Comparison (2026 Guide)

Second-gen vs first-gen GLP-1 agonist. Semaglutide (weekly injection) delivers 2x the weight loss of liraglutide (daily injection) with better HbA1c reduction. Both are GLP-1 receptor agonists but semaglutide has a longer half-life.