Mounjaro 'Magical' Until Pancreas Began Dying: Patient

Mounjaro Success Turns to Nightmare

Alisha Trafford, a 25-year-old healthcare assistant from Hull, hailed Mounjaro (tirzepatide) as 'magical' when she started it in February 2025. She purchased the £135 injection from an online pharmacy to lose weight and manage painful PCOS symptoms. In three months, she shed an impressive three-and-a-half stone.

Everything changed on May 28, 2025. Alisha experienced intense abdominal pain and vomiting, leading to an emergency hospital visit.

Diagnosis: Pancreatitis and Pancreatic Necrosis

Doctors diagnosed Alisha with pancreatitis, reportedly caused by Mounjaro. She endured multiple hospital admissions over the following months, with only brief respites between stays.

Further tests revealed pancreatic necrosis, where pancreas tissue dies due to lost blood supply. This serious complication can lead to infection, sepsis, and potentially fatal outcomes if untreated.

Alisha stopped Mounjaro after her first admission. Despite treatment with fluids and painkillers, she lost two stone in hospital from inability to eat. Her consultant attributed it firmly to the medication.

Symptoms and Hospital Struggles

Alisha described the pain as excruciating, mimicking a heart attack. After her initial week-long stay, she was readmitted within 48 hours.

• Agonizing pain prevented her from lifting her head or speaking.
• Exhaustion left her sleeping most of the time.
• Multiple admissions from May to August 2025 stunned her consultant, who noted her youth spared her a medically induced coma.

She faced another pancreatitis episode on December 6, 2025, and now lives with lifelong risk of recurrence.

Regrets and Life on Hold

Alisha says Mounjaro initially transformed her life, outperforming past weight loss attempts and improving PCOS. But now, her life is 'on hold.'

'If I knew this was what my life was going to be like then I never would have taken it,' Alisha said. 'I was independent and healthy; now I'm at constant risk.'

She's shifted to natural weight loss methods and urges caution.

What is Pancreatic Necrosis?

Per the NHS, pancreatitis involves short-term pancreas inflammation. Pancreatic necrosis occurs in severe cases when blood supply fails, causing tissue death.

• Tissue death can lead to infection.
• This risks sepsis and organ failure.
• Untreated, it can be fatal.

Lilly's Statement on Mounjaro Safety

Lilly, manufacturer of Mounjaro, emphasizes patient safety as their top priority. They monitor and report safety data actively.

The Mounjaro Patient Information Leaflet lists acute pancreatitis as an uncommon side effect (up to 1 in 100 people). It advises consulting a doctor if there's prior pancreatitis history and to report side effects.

Patients should ensure they use genuine Lilly medicine and seek professional advice for any issues.

Alisha's Warning for Mounjaro Users

Alisha advises: 'Don't ignore pain. If something feels wrong, get it checked—it's not worth the risk.'

Those on GLP-1 medications like Mounjaro should monitor for abdominal pain, vomiting, or unusual symptoms promptly.