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GLP-1 Medications

Doctor: You May Regain Weight After Stopping GLP-1 Drugs

Dr. Adrian Vale, MD
Reviewed by Dr. Adrian Vale, MDInternal Medicine · Board-Certified Obesity Medicine
·January 20, 2026·1 min read

On this page

  • Dr. Karan Rajan's Key Insights
  • Lifestyle Changes Are Essential
  • Not Forever for Everyone
  • Important Safety Notes

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Doctor Karan Rajan explains why you might regain weight after quitting GLP-1 drugs: they mimic treatments for chronic conditions like high blood pressure. Obesity requires ongoing management with lifestyle factors like diet, exercise, and sleep. Not everyone needs GLP-1s forever, but stopping without changes risks relapse.

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On this page

  • Dr. Karan Rajan's Key Insights
  • Lifestyle Changes Are Essential
  • Not Forever for Everyone
  • Important Safety Notes

GLP-1 medications, such as Ozempic and Wegovy, suppress appetite and aid weight loss for eligible NHS patients. However, they are not a permanent cure for obesity.

Dr. Karan Rajan's Key Insights

In a popular TikTok video, Dr. Karan Rajan (known as Dr. Raj online) addresses a common question: "Do you have to take a GLP-1 forever?"

He describes obesity as a chronic relapsing condition, cautioning against short-term use without comprehensive weight management.

"An uncomfortable truth: GLP-1s aren't cures. They act like blood pressure pills or statins—if you stop, you lose the effect."

Lifestyle Changes Are Essential

To sustain long-term health benefits beyond medication adherence, Dr. Rajan emphasizes non-negotiable lifestyle adjustments.

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  • Muscle mass preservation through strength training
  • Behavioral changes for sustainable habits
  • Quality sleep
  • High fiber intake
  • Adequate protein consumption
  • Stress management
  • Improved insulin sensitivity

Apps like Shotlee can help track GLP-1 doses and monitor these factors for better compliance.

Not Forever for Everyone

Dr. Rajan compares GLP-1s to eczema management: some avoid triggers without meds, others use occasional relief, and some need daily treatment.

All weight management medications must pair with a reduced-calorie diet and increased physical activity.

Important Safety Notes

  • Only use prescribed medications—never self-medicate
  • They may cause serious side effects and aren't safe for everyone
  • Consult a doctor for referral to specialist weight management services

Source Information

Originally published by EXPRESS.Read the original article →

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Dr. Adrian Vale, MD — Internal Medicine · Board-Certified Obesity Medicine
Medically reviewed

Dr. Adrian Vale, MD

Internal Medicine · Board-Certified Obesity Medicine

Dr. Adrian Vale is a board-certified internal medicine physician with a clinical focus on obesity medicine and metabolic health. He reviews Shotlee guides and articles on GLP-1 medications, peptide therapy, and weight-management protocols for clinical accuracy.

View all articles reviewed by Dr. Adrian Vale, MD
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