Semaglutide Week-by-Week

Note: Individual results vary significantly. These are typical experiences based on clinical trials and user reports.

Tracked reality is more modest — and far more varied — than headline trial numbers. Shotlee users with enough logged weigh-ins to measure show a median loss of 3.7% of body weight after 30 days of tracking (314 users) and 5.3% after 90 days (171 users). 84% are below their starting weight after the first month, easing to 75% by day 90 — and the spread is enormous: at 90 days, the top quarter of users are down 10.5% or more while the bottom quarter sit at 0.3% or less. Clinical trials report bigger averages, but those run a year-plus at full maintenance dose, while the first 90 days are mostly titration. Your own logged trend line — not a trial average — is the number that tells you whether your protocol is working. (Aggregated, anonymized Shotlee data as of July 2026.)