ENESDENewsletter →
Shotlee
Get the app
📖Complete Guide✅Updated 2026🔬Evidence-Based

Semaglutide vs Bariatric Surgery Guide (2026)

Complete Guide & Evidence (2026)

Semaglutide vs bariatric surgery for obesity. Weight loss comparison (15-17% vs 25-35%), cost analysis over 5 years, durability, and complication rates.

Download on theApp Store
Get it onGoogle Play
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
Semaglutide Vs SurgeryB12
SEMAGLUTIDE VS SURGERY
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Semaglutide Vs Surgery
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
Semaglutide Vs SurgeryRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
Semaglutide Vs SurgeryB12
SEMAGLUTIDE VS SURGERY
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Semaglutide Vs Surgery
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
Semaglutide Vs SurgeryRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Key Weight Loss Numbers

Mean total body weight loss in STEP trials at 68 weeks on 2.4 mg/week semaglutide.

Mean TBWL in SURMOUNT-1 at 72 weeks on 15 mg/week tirzepatide.

Average total body weight loss from Roux-en-Y gastric bypass at 1–2 years post-surgery.

02WHAT TO TRACK

Decision Framework

01
🔬
Choose GLP-1 Medication If…
BMI 27–40 with weight-related conditions. High surgical risk or surgical anxiety. Want reversible, medication-based approach. Willing to continue medication long-term. Have insurance coverage for GLP-
02
🔬
Consider Surgery If…
BMI >40 or >35 with severe comorbidities. Need durable results without daily medication. T2D remission is a primary goal. GLP-1s haven't provided adequate response. Insurance covers surgery but not me
03FAQ

Guide FAQs

Semaglutide vs bariatric surgery for obesity. Weight loss comparison (15-17% vs 25-35%), cost analysis over 5 years, durability, and complication rates.

Yes. Shotlee tracks GLP-1 and peptide doses, side effects, weight, and lab results — free to use.

Free · Always

Track Both Protocols in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

Download on theApp Store
Get it onGoogle Play

📚References & sources

🔗Keep exploring

All Guides
→
Trackers
→
Compare
→
Start tracking