What is MK-677?

MK-677 (ibutamoren) is a non-peptide, orally active growth hormone secretagogue receptor agonist. It mimics ghrelin โ€” the hunger hormone โ€” to stimulate pituitary GH release, which in turn raises IGF-1 levels. It is not a SARM despite being frequently grouped with them.

Clinical studies have shown MK-677 to increase muscle mass and bone mineral density, improve sleep architecture (particularly slow-wave and REM sleep), and elevate IGF-1 levels substantially. It has been studied in elderly populations for sarcopenia and in HIV patients for muscle wasting.

Note: MK-677 is a research compound not approved by the FDA for human use. It is commonly sold as a research chemical. Use is off-label and carries regulatory uncertainty. Always consult a healthcare provider before use.

Tracking Features

FAQ

What is MK-677?

An oral growth hormone secretagogue that mimics ghrelin to stimulate GH and IGF-1 release. Studied for muscle preservation, sleep improvement, and bone density. Not FDA-approved; used as a research compound.

What is the standard MK-677 dose?

10โ€“25mg once daily, typically in the evening before bed. Start at 10mg to assess tolerance โ€” hunger and water retention are common, especially at higher doses.

What side effects should I track?

Increased hunger (ghrelin effect), water retention, vivid dreams, morning lethargy, and blood sugar changes. Tracking these in Shotlee alongside your dose helps you find the optimal protocol.

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