Loading.
Preparing your Shotlee experience
Preparing your Shotlee experience

Bariatric surgery significantly impacts glucose and insulin responses. This post explores the nuances of these changes, focusing on the impact of different surgical procedures, sex-based differences, and the implications for personalized treatment of metabolic conditions.
Bariatric surgery is a powerful tool for weight loss and improving metabolic health. But how exactly does it change the way our bodies process sugar (glucose) and insulin? A recent study published in Communications Medicine sheds light on these complex dynamics, revealing important differences between surgical procedures and even between men and women.
The study used a sophisticated computational model to analyze glucose and insulin responses after bariatric surgery, specifically looking at Roux-en-Y gastric bypass (RYGB) and One-Anastomosis Gastric Bypass (OAGB). Researchers found that both surgeries led to sharper and earlier glucose-insulin peaks, along with faster restoration to baseline. This means the body is more efficient at clearing glucose from the bloodstream after eating.
But there were key differences:
While RYGB's sharper glucose peaks could potentially have vascular implications, studies also show it improves hypertension. OAGB might be a safer choice for individuals with a history of cardiovascular disease due to its more gradual glucose absorption. Ultimately, both procedures offer substantial glycemic benefits.
These metabolic benefits are likely linked to changes in the gut after surgery. Specifically, there's an enhanced stimulation of L-cells, leading to a significant increase in the secretion of GLP-1, a gut hormone that stimulates insulin secretion and contributes to glycemic control. The increased GLP-1 secretion post-surgery helps enhance insulin sensitivity and improves glucose clearance.
The study also uncovered significant sex-based differences. Men exhibited a more unhealthy glucose-insulin profile throughout weight loss, with higher peak glucose levels. This highlights the importance of considering sex when developing personalized treatment strategies for metabolic conditions. According to a study in Diabetes Care, hormonal differences play a significant role in how men and women process glucose.
So, what can we learn from this research?
Focusing on metabolic health includes paying close attention to diet, exercise, and overall lifestyle. For example, peptide therapy, including medications like semaglutide, sold under the brand names Ozempic and Wegovy, can improve glycemic control. Even other peptides like BPC-157, which is known for its healing properties, may have other benefits in this area.
Understanding the intricate glucose-insulin dynamics after bariatric surgery is crucial for optimizing patient outcomes. This study highlights the importance of personalized treatment strategies, considering both the type of surgery and individual characteristics like sex. By closely monitoring glucose levels and embracing a healthy lifestyle, individuals can unlock the secrets to improved metabolic health and longevity.
⚠️ Disclaimer: This article is for informational purposes only. Consult your healthcare provider before starting any medication or supplement.
Original content from Nature
View Original Article
Cipla and Eli Lilly are joining forces to expand access to tirzepatide, a GLP-1 receptor agonist, in India. This partnership aims to address the growing concerns of type 2 diabetes and obesity by distributing the drug under the brand name Yurpeak.

Emerging research highlights the potential of alpha-ketoglutarate (AKG) in addressing insulin resistance and improving metabolic health. This blog post explores the science behind AKG and its potential benefits for longevity and overall wellness.
Monitor GLP-1 medications, peptide therapy, weight loss, and wellness metrics with our comprehensive health tracking app. Join thousands of users taking control of their health!
Start Tracking Free Forever! ✨