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Expected Weight Loss by Medication

Clinical Trial Results (68 weeks)Average
Ozempic 1mgSemaglutide
~10%Body Weight
For a 200 lb person, expect to lose approximately 20 lbs over 68 weeks.
Wegovy 2.4mgSemaglutide
~15%Body Weight
For a 200 lb person, expect to lose approximately 30 lbs over 68 weeks. Top performers lost 20%+ (40 lbs).
Mounjaro 15mgTirzepatide
~21%Body Weight
For a 200 lb person, expect to lose approximately 42 lbs over 72 weeks. Top performers lost 25%+ (50 lbs).
Zepbound 15mgTirzepatide
~21%Body Weight
Same active ingredient as Mounjaro but FDA-approved specifically for weight loss.
Retatrutide 12mgInvestigationalPhase 3
~24%Body Weight
Not yet FDA approved. Phase 3 trial data shows ~24% weight loss at 48 weeks. Projected release: 2026-2027. Triple agonist (GIP/GLP-1/glucagon).

Typical Weight Loss Timeline

Weeks 1-42-5 lbsInitial water weight and appetite reduction
Months 2-35-10 lbsFat loss begins as you titrate up
Months 4-615-25 lbsMaximum dose, steady loss phase
Year 1+30-50+ lbsMaintenance dose, results vary

FAQ

How much weight will I lose on Ozempic in 3 months?

Most people lose 5-10% of their body weight in the first 3 months. For a 200 lb person, that's 10-20 lbs. Results depend on diet, exercise, and how well you tolerate dose increases.

Is Mounjaro better than Ozempic for weight loss?

Clinical trials show tirzepatide (Mounjaro/Zepbound) produces about 5-6% more weight loss than semaglutide (Ozempic/Wegovy). However, individual results vary significantly.

What if I'm not losing weight on GLP-1?

Weight loss can stall during titration. Use Shotlee to track your weight daily and identify patterns. If you've plateaued for 4+ weeks at maintenance dose, talk to your doctor.

Track Your Progress with Shotlee

Log your weight daily, track injections, and visualize your weight loss velocity over time.

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