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Руководство по Foundayo (Орфорглипрон)
Таблетка GLP-1 для похудения от Eli Lilly
Полное руководство по Foundayo (orforglipron) — первому непептидному пероральному препарату GLP-1 для управления весом.
ATTAIN-1 (72 недели)
До 12.4 кг
Снижение веса (Фаза 2)
~14.7%
Снижение HbA1c
До 2.1%
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Medication Supply
Foundayo
~42 days left · Mar 15
B12
~88 days left · May 8
Retatrutide
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
FoundayoRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Medication Supply
Foundayo
~42 days left · Mar 15
B12
~88 days left · May 8
Retatrutide
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
FoundayoRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND
Что такое Foundayo (Орфорглипрон)?
Foundayo — это торговое название орфорглипрона (LY3502970), перорального агониста рецепторов GLP-1, разработанного компанией Eli Lilly для борьбы с ожирением и диабетом 2 типа. В отличие от инъекционных препаратов, таких как Wegovy или Ozempic, Foundayo — это таблетка для приема один раз в день.
Уникальность Foundayo: это непептидное соединение. Оно не разрушается в пищеварительной системе, что позволяет принимать его в любое время с едой — без голодания и строгих временных рамок.
Foundayo знаменует собой важный сдвиг в терапии GLP-1. Хотя Rybelsus (пероральный семаглутид) уже существует, он требует 30-минутного голодания и имеет низкую биодоступность. Foundayo устраняет эти ограничения.
02KEY NUMBERS
Результаты клинических испытаний
📈
ATTAIN-1 (72 недели)
0.0кг
Среднее снижение веса у взрослых без диабета в исследовании фазы 3.
💪
Снижение веса (Фаза 2)
0.0%
Снижение массы тела на 36-й неделе (Wharton et al., NEJM 2023).
🏆
Снижение HbA1c
0.0%
Снижение гликированного гемоглобина в исследованиях ACHIEVE.
03MECHANICS
Ожидаемый график дозирования
1
Activates GLP-1 receptors in the brain to reduce appetite and cravings
2
Slows gastric emptying to prolong feelings of fullness after meals
3
Enhances glucose-dependent insulin secretion for better blood sugar control
4
Small molecule structure survives stomach acid without special formulation
5
Absorbs effectively regardless of food intake — no fasting required
6
Maintains consistent blood levels with once-daily oral dosing
04DOSING
Foundayo против инъекций
Week 1-2
3 mg daily
Starting dose
Week 3-4
6 mg daily
First escalation
Week 5-8
12-24 mg daily
Titration phase
Maintenance
36-45 mg daily
Target dose
05WHAT TO TRACK
Foundayo vs Injectable GLP-1s
01
💊
Oral Convenience
Once-daily pill taken with or without food. No needles, no refrigeration, no injection site rotation. Ideal for needle-phobic patients.
02
🔬
Non-Peptide Structure
Unlike Rybelsus (oral semaglutide), Foundayo's small molecule design means no fasting requirement and better absorption flexibility.
03
🏭
Easier Manufacturing
Small molecules are cheaper and faster to produce than biologic peptides, potentially reducing drug shortages and lowering costs.
04
🌍
Global Access Potential
No cold chain storage required for pills. Easier worldwide distribution including developing markets where refrigeration is limited.
06WHAT TO TRACK
Who Is Foundayo Best For?
01
✅
Ideal Candidates
Needle-phobic patients. Those who struggled with Rybelsus fasting restrictions. People with irregular schedules. Patients starting GLP-1 therapy for the first time. Those who prefer daily pills over weekly injections.
02
⚠️
Consider Alternatives If
You need maximum weight loss (injectable tirzepatide may be stronger). You prefer weekly dosing over daily pills. You respond well to current injectable GLP-1s. You want dual GIP/GLP-1 agonist effects (tirzepatide).
07WHAT TO TRACK
Side Effects
01
🔬
Common (Similar to All GLP-1s)
Nausea (most common, especially during dose escalation). Vomiting. Diarrhea. Constipation. Decreased appetite. These typically improve over time and with slower dose titration.
02
📊
Clinical Trial Observations
Side effect profile similar to injectable GLP-1s. GI effects typically mild to moderate in severity. Improved significantly with gradual dose escalation. No unexpected safety signals in Phase 3 data. Well-tolerated overall in ATTAIN and ACHIEVE trials.
08TIMELINE
Development Timeline
2023:
Phase 2 results published in NEJM showing ~14.7% weight loss at 36 weeks
2025:
Positive Phase 3 ATTAIN (obesity) and ACHIEVE (T2D) trial readouts reported
Late 2025:
Eli Lilly announces "Foundayo" as the brand name for orforglipron
2026:
Regulatory submissions to FDA for obesity and type 2 diabetes indications
Expected 2026-2027:
Potential FDA approval and commercial launch
09WHAT TO TRACK
Frequently Asked Questions
01
💊
Is Foundayo the same as orforglipron?
Yes. Foundayo is the brand name chosen by Eli Lilly for orforglipron (LY3502970). They are the same compound — a non-peptide oral GLP-1 receptor agonist.
02
🔬
Is Foundayo as effective as Ozempic?
Phase 3 ATTAIN-1 data shows meaningful weight loss. Direct cross-drug comparisons depend on study population and dose, but oral convenience is a major advantage for adherence.
03
🍽️
Can I really take it with food?
Yes. Unlike Rybelsus, Foundayo's small molecule structure allows absorption regardless of food intake. Take it with any meal or without food — no restrictions.
04
⏰
Why daily instead of weekly?
Small molecules are cleared faster than peptides. Daily dosing with zero restrictions may be preferable to weekly injections or weekly pills with strict fasting rules.
10FAQ
Вопросы по руководству
Это таблетированная форма препарата GLP-1 от Eli Lilly для похудения, которую не нужно колоть.
По состоянию на 2026 год препарат прошел фазу 3 испытаний и находится на рассмотрении регуляторов. Ожидается выход на рынок в 2026-2027 годах.
Да, Shotlee поддерживает логирование доз Foundayo, веса и побочных эффектов.
Free · Always
Отслеживайте протокол Foundayo в Shotlee
Бесплатный журнал дозировок, учет побочных эффектов и мониторинг здоровья для вашего протокола Foundayo (orforglipron).
📚References & sources
1