📖Complete Guide✅Updated 2026🔬Evidence-Based
NAD+ Guide (2026)
Complete Guide & Evidence (2026)
Nicotinamide adenine dinucleotide — essential coenzyme for cellular energy production and DNA repair.
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Medication Supply
NAD+
~42 days left · Mar 15
B12
~88 days left · May 8
Retatrutide
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
NAD+Retatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Medication Supply
NAD+
~42 days left · Mar 15
B12
~88 days left · May 8
Retatrutide
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
NAD+Retatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01WHAT TO TRACK
How NAD+ Works
01
🔬
Energy Metabolism
Shuttles electrons in ATP production (Krebs cycle). Powers oxidative phosphorylation in mitochondria. Rate-limiting factor for cellular energy output
02
🔬
Sirtuin Activation
Sirtuins 1–7 require NAD+ as substrate. SIRT1/SIRT3 regulate metabolism and stress response. SIRT6 repairs DNA double-strand breaks
03
🔬
DNA Repair (PARP)
PARP enzymes consume NAD+ to repair DNA damage. Higher NAD+ = faster, more complete DNA repair. Critical under UV, toxin, or oxidative stress
02BACKGROUND
Clinical Data
Reduction in whole-blood NAD+ levels from age 40 to 60 in human studies.
Daily oral dose shown to raise blood NAD+ in multiple human trials.
Typical IV infusion dose given over 4–8 hours in clinical longevity settings.
03WHAT TO TRACK
Vital Protocol FAQs
01
🔬
What is NAD+ and why does it matter?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for energy metabolism, DNA repair, and activating sirtuins — proteins that regulate aging and stress respon
02
🔬
What is the difference between NMN, NR, and NAD+?
NAD+ cannot cross cell membranes efficiently when taken orally, so supplementation typically uses precursors. NMN (nicotinamide mononucleotide) is one step away from NAD+ in synthesis; NR (nicotinamid
03
🧬
What benefits has NAD+ supplementation shown in humans?
Human trials with NMN and NR have shown: improved insulin sensitivity, increased physical endurance, improved NAD+ blood levels, reduced aging biomarkers (including DNA damage markers), and improved m
04
🔬
Is IV NAD+ better than oral NMN/NR?
IV NAD+ delivers NAD+ directly into the bloodstream, bypassing gut absorption and conversion steps, and produces more immediate effects including energy surges and cognitive clarity. Oral NMN/NR is mo
04FAQ
Guide FAQs
Nicotinamide adenine dinucleotide — essential coenzyme for cellular energy production and DNA repair.
Yes. Shotlee supports tracking NAD+ doses, side effects, and health metrics. It is free to use.
Free · Always
Track Your NAD+ Protocol in Shotlee
Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.