ENESDENewsletter →
Shotlee
Get the app
📖Panduan Lengkap✅Diperbarui 2026🔬Berbasis Bukti

Panduan Metformin (2026)

Panduan Lengkap & Bukti Ilmiah (2026)

Obat lini pertama diabetes Tipe 2 yang kini diteliti untuk umur panjang (uji klinis TAME). Mengaktifkan AMPK, mengurangi pensinyalan insulin/IGF-1, dan memiliki sifat anti-kanker.

Unduh diApp Store
Dapatkan diGoogle Play
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
MetforminB12
METFORMIN
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Metformin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
MetforminRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
MetforminB12
METFORMIN
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Metformin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
MetforminRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01WHAT TO TRACK

Cara Kerja Metformin

01
🔬
AMPK Activation
Activates the cellular energy sensor AMPK. Mimics caloric restriction signaling. Reduces hepatic glucose production
02
🔬
mTOR Inhibition
Indirectly inhibits mTORC1 via AMPK. Promotes autophagy — cellular cleanup. Reduces protein synthesis — longevity signal
03
🎯
Metabolic Effects
Improves insulin sensitivity. Lowers fasting glucose and HbA1c. Mild reduction in body weight (1–3 kg)
02BACKGROUND

Data Kunci

Pasien yang saat ini menggunakan metformin di seluruh dunia — obat diabetes yang paling banyak diresepkan.

Dosis yang sedang diuji dalam uji klinis manusia bersejarah 'Targeting Aging with Metformin'.

Proporsi pengguna metformin jangka panjang dengan defisiensi B12 tanpa suplementasi.

03DEEP DIVE

Ikhtisar Protokol Metformin

Pantau: Kadar B12 tahunan, eGFR, HbA1c. Hindari pada hari latihan fisik berat (kontroversial) dan hentikan sebelum pencitraan kontras. Gunakan jenis extended-release untuk meminimalkan efek samping pencernaan.

04DEEP DIVE

Lini Masa Riset Umur Panjang Metformin

Metformin pertama kali dideskripsikan di Prancis. Digunakan untuk T2D di Eropa sejak 1958.

Makalah NEJM: penderita diabetes yang mengonsumsi metformin hidup lebih lama dibanding non-diabetes yang setara — sinyal umur panjang yang bersejarah.

FDA menyetujui protokol uji klinis TAME (Targeting Aging with Metformin) — uji penuaan pertama yang disetujui FDA.

Uji klinis TAME aktif merekrut ~3.000 orang dewasa sehat usia 65–79 tahun. Hasil diharapkan keluar pada 2027.

05WHAT TO TRACK

FAQ Protokol Vital

01
🛡️
Why are healthy people taking metformin for longevity?
Metformin, the most prescribed diabetes drug in the world, has attracted longevity interest because of its AMPK activation (same pathway as caloric restriction), mTOR inhibition, and observational dat
02
💉
What is the metformin longevity dose?
For longevity purposes (off-label), physicians typically prescribe 500–1000 mg/day, often taken at night or with meals to minimize GI side effects. The TAME trial uses 1500 mg/day. Diabetic doses go u
03
🔬
Does metformin interfere with exercise adaptations?
This is a genuine controversy. A 2023 study showed high-dose metformin blunted some exercise adaptations (VO2max gains) in older adults. However, lower doses and specific timing (avoiding pre-workout
04
🔬
Is metformin safe for non-diabetics?
Metformin has a very long safety record with billions of patient-years of use in diabetics. The primary risk in non-diabetics is hypoglycemia (rare at low doses) and vitamin B12 depletion with long-te
06FAQ

FAQ Panduan

Obat lini pertama diabetes Tipe 2 yang kini diteliti untuk umur panjang (uji klinis TAME). Mengaktifkan AMPK, mengurangi pensinyalan insulin/IGF-1, dan memiliki sifat anti-kanker.

Ya. Shotlee mendukung pelacakan dosis Metformin, efek samping, dan metrik kesehatan. Aplikasi ini gratis untuk digunakan.

Free · Always

Lacak Protokol Metformin Anda di Shotlee

Pencatatan dosis gratis, pelacakan efek samping, dan pemantauan metrik kesehatan untuk protokol lengkap Anda.

Unduh diApp Store
Dapatkan diGoogle Play

📚References & sources

🔗Keep exploring

Semua Panduan
→
Pelacak
→
Bandingkan
→
Start tracking