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📖Complete Guide✅Updated 2026🔬Evidence-Based

Elamipretide Guide (2026)

Complete Guide & Evidence (2026)

Mitochondria-targeted tetrapeptide (SS-31/Bendavia) that stabilizes cardiolipin in the inner mitochondrial membrane.

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Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
ElamipretideB12
ELAMIPRETIDE
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Elamipretide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
ElamipretideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
ElamipretideB12
ELAMIPRETIDE
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Elamipretide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
ElamipretideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01WHAT TO TRACK

The Mitochondrial Mechanism

01
🔬
Cardiolipin Stabilization
Binds to cardiolipin in inner mitochondrial membrane. Protects from oxidative degradation. Restores cristae architecture for efficient ATP production
02
🔬
Electron Transport Chain
Improves Complex I and Complex III efficiency. Reduces electron leak and superoxide generation. Increases ATP:ADP ratio in deficient cells
03
🔬
ROS Reduction
Directly quenches mitochondrial reactive oxygen species. Reduces oxidative stress in cardiomyocytes. Protects against ischemia-reperfusion injury
04
🔬
Why Cardiolipin Matters
Cardiolipin is found only in the inner mitochondrial membrane and is essential for cristae shape — the folds that house ATP synthase. When cardiolipin is damaged by oxidative stress, cristae flatten,
02BACKGROUND

Clinical Trial Snapshots

Six-minute walk test improvement in TAZPOWER trial for Barth syndrome patients.

Subcutaneous dose used in Phase 2 cardiac trials (Barth syndrome, heart failure).

Active Phase 1–3 trials studying Barth syndrome, heart failure, and mitochondrial myopathy.

03DEEP DIVE

Elamipretide Protocol Overview

Note: Elamipretide has not been FDA approved. It is an investigational drug. Clinical trial participation is the safest way to access it. Research-grade versions require CoA verification and sterile reconstitution.

04WHAT TO TRACK

Vital Protocol FAQs

01
🔬
What is elamipretide (SS-31)?
Elamipretide (also known as SS-31 or Bendavia) is a mitochondria-targeted tetrapeptide (D-Arg-2'6'-dimethylTyr-Lys-Phe-NH2) that specifically accumulates in the inner mitochondrial membrane. It works
02
🔬
What conditions is elamipretide being studied for?
Elamipretide has shown promising results in Phase 2 trials for Barth syndrome (a rare genetic heart condition), heart failure with reduced ejection fraction, and mitochondrial myopathy. In a Phase 2 t
03
💉
What is the elamipretide dosing protocol?
Clinical trial doses for Barth syndrome and heart failure used subcutaneous infusions of 0.05–0.25 mg/kg/day. Research protocols in the biohacking community typically use 5–10 mg subcutaneous daily. E
04
🔬
What are elamipretide's effects on exercise capacity?
In the TAZPOWER trial for Barth syndrome patients, elamipretide significantly improved the 6-minute walk test (exercise capacity) vs. placebo. In heart failure studies, improvements in left ventricula
05FAQ

Guide FAQs

Mitochondria-targeted tetrapeptide (SS-31/Bendavia) that stabilizes cardiolipin in the inner mitochondrial membrane.

Yes. Shotlee supports tracking Elamipretide doses, side effects, and health metrics. It is free to use.

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Track Your Elamipretide Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

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📚References & sources

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