Zepbound Dosage Chart
The 2.5mg → 15mg weight-loss schedule, plus dose-to-units
Zepbound (tirzepatide) is FDA approved for weight management and titrated weekly from 2.5mg up to a maximum of 15mg. This chart shows the standard escalation schedule and converts each dose to syringe units for the single-dose vials. Always follow your prescriber and product label.
How Zepbound titration works
Zepbound is the obesity-indicated brand of tirzepatide, a once-weekly injection that starts at 2.5mg and increases in 2.5mg steps about every 4 weeks. The 2.5mg starter dose builds tolerance and is not meant to be therapeutic; you move up only as side effects allow.
Recommended maintenance doses are 5mg, 10mg, or 15mg. Many people lose meaningful weight at 5mg or 10mg and hold there — there is no requirement to reach 15mg.
Zepbound titration schedule (2.5mg → 15mg)
| Dose | Typical timing | Purpose |
|---|---|---|
| 2.5 mg | Weeks 1–4 | Starter / tolerance dose (not therapeutic)Best |
| 5 mg | Weeks 5–8 | First maintenance option |
| 7.5 mg | Weeks 9–12 | Step-up if more effect needed |
| 10 mg | Weeks 13–16 | Common maintenance dose |
| 12.5 mg | Weeks 17–20 | Step-up if tolerated |
| 15 mg | Week 21+ | Maximum dose |
Zepbound dose to syringe units (vials)
| Dose | 5 mg/mL | 10 mg/mL | 20 mg/mL |
|---|---|---|---|
| 2.5 mg | 0.5 mL → 50 | 0.25 mL → 25 | 0.13 mL → 13Best |
| 5 mg | 1.0 mL → 100 | 0.5 mL → 50 | 0.25 mL → 25 |
| 7.5 mg | 1.5 mL → 150* | 0.75 mL → 75 | 0.38 mL → 38 |
| 10 mg | 2.0 mL → 200* | 1.0 mL → 100 | 0.5 mL → 50 |
| 12.5 mg | 2.5 mL → 250* | 1.25 mL → 125* | 0.63 mL → 63 |
| 15 mg | 3.0 mL → 300* | 1.5 mL → 150* | 0.75 mL → 75 |
Escalation tips & safety
You can hold a dose longer or step back down if side effects are difficult — slower titration is a common way to manage nausea, constipation, and fatigue. There is no rule that you must escalate on a fixed timeline.
This chart is a reference, not medical advice. Your prescriber sets your schedule based on your response and goals; confirm dose and concentration carefully if you use vials.
Guide FAQs
The maximum Zepbound dose is 15mg once weekly. Maintenance can also be 5mg or 10mg — you do not need to reach 15mg if a lower dose drives good weight loss and is well tolerated.
Typically by one 2.5mg step about every 4 weeks, only as tolerated. Many people stay longer at a dose to manage side effects, which is fine.
For vials, units depend on concentration. At 10mg/mL: 2.5mg = 25 units, 5mg = 50, 10mg = 100. Branded Zepbound pens are pre-measured, so units only apply to the single-dose vials or compounded tirzepatide.
Yes — both are tirzepatide with the identical 2.5mg→15mg titration. Zepbound is approved for weight management and Mounjaro for type 2 diabetes, but the dose ladder is the same.
Yes. Shotlee logs each weekly dose, reminds you when to escalate, and tracks side effects and weight — free.
Track Your Zepbound Schedule in Shotlee
Log doses, get escalation reminders, and track side effects and weight — free.