📖Полное руководствоОбновлено 2026🔬На основе доказательств

Руководство по Тесаморелину

Дозировка Egrifta, снижение жира и протокол

Полное руководство по Тесаморелину (Egrifta): одобренный FDA аналог GHRH для борьбы с висцеральным жиром.

Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
ACTIVE MEDICATIONS
TesamorelinB12
TESAMORELIN
🔥 14
2
days away
Thursday · 7.5mg
Medication Supply
Tesamorelin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
TesamorelinRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
ACTIVE MEDICATIONS
TesamorelinB12
TESAMORELIN
🔥 14
2
days away
Thursday · 7.5mg
Medication Supply
Tesamorelin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
TesamorelinRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Egrifta: Одобренный FDA аналог GHRH

Тесаморелин (бренд Egrifta) — это модифицированный аналог GHRH, который стимулирует выброс гормона роста с превосходной стабильностью. В клинических испытаниях он показал снижение висцерального жира на 15–20%.

02DEEP DIVE

Механизм и ключевые эффекты

Tesamorelin is a synthetic analog of endogenous GHRH (growth hormone-releasing hormone) with a trans-3-hexenoic acid chemical modification at the N-terminus. This modification stabilizes the molecule against enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), giving Tesamorelin a longer active half-life and more potent pituitary stimulation than native GHRH or Sermorelin.

The FDA approved Tesamorelin as Egrifta in 2010 specifically for reducing excess abdominal visceral fat in HIV-positive adults on antiretroviral therapy (ART). HIV lipodystrophy — characterized by central fat accumulation despite peripheral fat loss — is a major metabolic complication of long-term ART. Tesamorelin addresses this by restoring GH pulsatility and promoting visceral fat lipolysis.

Off-label, Tesamorelin has attracted interest from bodybuilders, biohackers, and anti-aging practitioners for its powerful visceral fat reduction, IGF-1 elevation, and potential cognitive benefits. Research also suggests Tesamorelin may improve cognition in mild cognitive impairment — a finding from National Institute on Aging-funded trials at Vanderbilt University.

03WHAT TO TRACK

Mechanism & Key Effects

01
🔬
GHRH Receptor Binding
Tesamorelin binds pituitary GHRH receptors with high affinity, triggering pulsatile GH secretion. The trans-3-hexenoic acid modification protects against DPP-4 cleavage — the primary metabolic enzyme
02
⚖️
Visceral Fat Lipolysis
GH stimulates hormone-sensitive lipase in visceral adipocytes, promoting lipolysis of visceral adipose tissue (VAT). Phase III trials demonstrated 15–20% reductions in VAT area by CT scan over 26 week
03
🔬
IGF-1 & Anabolism
Tesamorelin increases IGF-1 by 60–100% in clinical trials. Elevated IGF-1 drives anabolic effects including increased lean muscle mass, improved insulin sensitivity in muscle tissue, enhanced collagen
04
Cognitive Benefits
A Vanderbilt NIA-funded RCT found Tesamorelin improved executive function and verbal memory in older adults with mild cognitive impairment over 20 weeks. GH and IGF-1 both act on brain tissue — increa
04DEEP DIVE

Tesamorelin Dosing Protocol

Inject into abdominal subcutaneous tissue, rotating sites. Monitor IGF-1 at baseline and every 6 weeks. Target IGF-1: 200–350 ng/mL. Use Shotlee to track daily injections and body composition changes.

05WHAT TO TRACK

Side Effects & Considerations

01
⚠️
Common Side Effects
Injection site reactions: redness, bruising, pain (most common). Peripheral edema (fluid retention) — dose-dependent. Arthralgia (joint pain) — GH-mediated. Carpal tunnel symptoms at higher doses. Glu
02
🔬
Contraindications
Active malignancy (theoretical IGF-1 cancer concern). Diabetic retinopathy. Pregnancy or breastfeeding. Hypersensitivity to Tesamorelin or mannitol. Disrupted hypothalamic-pituitary axis
06FAQ

Вопросы по руководству

Это пептид, стимулирующий выработку собственного гормона роста, эффективно сжигающий висцеральный жир.

Препарат одобрен FDA для определенных состояний, но требует медицинского контроля уровня IGF-1 и сахара в крови.

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📚References & sources

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