Руководство по Тесаморелину
Дозировка Egrifta, снижение жира и протокол
Полное руководство по Тесаморелину (Egrifta): одобренный FDA аналог GHRH для борьбы с висцеральным жиром.
Egrifta: Одобренный FDA аналог GHRH
Тесаморелин (бренд Egrifta) — это модифицированный аналог GHRH, который стимулирует выброс гормона роста с превосходной стабильностью. В клинических испытаниях он показал снижение висцерального жира на 15–20%.
Механизм и ключевые эффекты
Tesamorelin is a synthetic analog of endogenous GHRH (growth hormone-releasing hormone) with a trans-3-hexenoic acid chemical modification at the N-terminus. This modification stabilizes the molecule against enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), giving Tesamorelin a longer active half-life and more potent pituitary stimulation than native GHRH or Sermorelin.
The FDA approved Tesamorelin as Egrifta in 2010 specifically for reducing excess abdominal visceral fat in HIV-positive adults on antiretroviral therapy (ART). HIV lipodystrophy — characterized by central fat accumulation despite peripheral fat loss — is a major metabolic complication of long-term ART. Tesamorelin addresses this by restoring GH pulsatility and promoting visceral fat lipolysis.
Off-label, Tesamorelin has attracted interest from bodybuilders, biohackers, and anti-aging practitioners for its powerful visceral fat reduction, IGF-1 elevation, and potential cognitive benefits. Research also suggests Tesamorelin may improve cognition in mild cognitive impairment — a finding from National Institute on Aging-funded trials at Vanderbilt University.
Mechanism & Key Effects
GHRH Receptor Binding
Tesamorelin binds pituitary GHRH receptors with high affinity, triggering pulsatile GH secretion. The trans-3-hexenoic acid modification protects against DPP-4 cleavage — the primary metabolic enzyme
Visceral Fat Lipolysis
GH stimulates hormone-sensitive lipase in visceral adipocytes, promoting lipolysis of visceral adipose tissue (VAT). Phase III trials demonstrated 15–20% reductions in VAT area by CT scan over 26 week
IGF-1 & Anabolism
Tesamorelin increases IGF-1 by 60–100% in clinical trials. Elevated IGF-1 drives anabolic effects including increased lean muscle mass, improved insulin sensitivity in muscle tissue, enhanced collagen
Cognitive Benefits
A Vanderbilt NIA-funded RCT found Tesamorelin improved executive function and verbal memory in older adults with mild cognitive impairment over 20 weeks. GH and IGF-1 both act on brain tissue — increa
Tesamorelin Dosing Protocol
Inject into abdominal subcutaneous tissue, rotating sites. Monitor IGF-1 at baseline and every 6 weeks. Target IGF-1: 200–350 ng/mL. Use Shotlee to track daily injections and body composition changes.
Side Effects & Considerations
Common Side Effects
Injection site reactions: redness, bruising, pain (most common). Peripheral edema (fluid retention) — dose-dependent. Arthralgia (joint pain) — GH-mediated. Carpal tunnel symptoms at higher doses. Glu
Contraindications
Active malignancy (theoretical IGF-1 cancer concern). Diabetic retinopathy. Pregnancy or breastfeeding. Hypersensitivity to Tesamorelin or mannitol. Disrupted hypothalamic-pituitary axis
Вопросы по руководству
Это пептид, стимулирующий выработку собственного гормона роста, эффективно сжигающий висцеральный жир.
Препарат одобрен FDA для определенных состояний, но требует медицинского контроля уровня IGF-1 и сахара в крови.
Источники
- [1]Clinical TrialFalutz J et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370.
- [2]Clinical TrialStanley TL et al. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA. 2014;312(4):380-389.
- [3]Clinical TrialBaker LD et al. Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults. Arch Neurol. 2012;69(11):1420-1429.
- [4]FDAEgrifta (tesamorelin for injection). FDA Prescribing Information. Theratechnologies Inc. 2010.
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