Rapamycin Tracker
Track Your Rapamycin Longevity Protocol — Doses & Side Effects
Rapamycin (sirolimus) is the most researched longevity compound, extending lifespan in every animal species tested. Track weekly doses, side effects, and bloodwork with the free Shotlee app.
What is Rapamycin?
Rapamycin (sirolimus) is an mTOR (mechanistic target of rapamycin) inhibitor discovered in bacteria from Easter Island soil. It was developed as an organ transplant immunosuppressant and cancer drug. At the much lower, intermittent doses used for longevity, it works by periodically inhibiting mTOR complex 1, triggering cellular cleanup (autophagy) and reducing age-related cellular senescence.
Rapamycin has extended median and maximum lifespan in mice, even when started late in life. It is the subject of the Dog Aging Project, a clinical study testing rapamycin in companion dogs. Human trials for longevity are ongoing (PEARL trial, TRIAD trial). Peter Attia, Bryan Johnson, and other longevity physicians have publicly used it.
Important: Rapamycin is FDA-approved only for transplant immunosuppression and cancer. Off-label longevity use requires a prescription and close medical monitoring. Systematic tracking of doses and side effects is essential.
Tracking Features
FAQ
What is rapamycin used for in longevity?
Intermittent low-dose rapamycin inhibits mTOR complex 1, triggering autophagy and reducing cellular senescence. It has extended lifespan in mice, yeast, flies, and worms. Off-label human use for longevity is growing, driven by physicians like Peter Attia.
What is the typical longevity dose?
3–10mg once per week off-label. Bryan Johnson uses 13mg/week with medical supervision. Start low (3mg/week) and titrate with physician guidance and regular bloodwork.
What should I monitor while taking rapamycin?
Lipid panels (rapamycin can raise triglycerides and LDL), CBC, sirolimus blood levels (optional), and side effects like mouth sores, acne, and infection susceptibility. Shotlee lets you log all of these.