What Is Icosema?

Icosema is Novo Nordisk\'s investigational fixed-ratio combination of insulin icodec (a once-weekly basal insulin) and semaglutide (a GLP-1 receptor agonist). By combining both in a single weekly injection, it aims to simplify diabetes management while providing the metabolic benefits of GLP-1 therapy alongside insulin\'s glucose-lowering power.

Track your current protocol in Shotlee while this science evolves. Having clean historical data means you can compare outcomes with precision if you ever switch medications.

How It Works

Insulin Icodec

  • • Once-weekly basal insulin
  • • Steady glucose control
  • • Reduces injection burden
  • • Track insulin data in Shotlee

Semaglutide Component

  • • GLP-1 receptor agonist
  • • Appetite suppression
  • • Weight management benefits
  • • Log weight trends in Shotlee

Combination Advantage

  • • Single weekly injection
  • • Simplified regimen
  • • Dual metabolic action
  • • Monitor both effects in Shotlee

Why This Matters

Managing both insulin and GLP-1 therapy in a single weekly injection dramatically simplifies treatment for people with Type 2 diabetes. Tracking dose adherence and metabolic markers in Shotlee ensures you stay on top of your protocol.

Clinical Data

Phase 3COMBINE Trials

Multiple Phase 3 trials (COMBINE program) are evaluating Icosema in Type 2 diabetes populations.

Side Effects

  • • Hypoglycemia (insulin component)
  • • GI symptoms (semaglutide component)
  • • Injection site reactions
  • • Track all side effects in Shotlee

Vital Protocol FAQs

What is Icosema?

Icosema is a fixed-ratio combination of once-weekly insulin icodec and semaglutide in a single injection. It is designed for people with Type 2 diabetes. Track your insulin and GLP-1 protocols together in the Shotlee app.

Is Icosema approved?

Icosema is still in Phase 3 trials. Use Shotlee to track your current insulin and GLP-1 protocols while awaiting results.

Prepare for Better Protocol Outcomes

Track your protocol with Shotlee and make every decision from clean, visible data instead of guesswork.

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