📖 Complete Guide Updated 2026🔬 Evidence-Based

Icosema Guide

Novo Nordisk

Complete guide to Icosema. Icosema is Novo Nordisk

Novo Nordisk\'s Fixed-Ratio Insulin Icodec + Semaglutide Combination

Icosema is Novo Nordisk\'s investigational fixed-ratio combination of insulin icodec (a once-weekly basal insulin) and semaglutide (a GLP-1 receptor agonist). By combining both in a single weekly injection, it aims to simplify diabetes management while providing the metabolic benefits of GLP-1 therapy alongside insulin\'s glucose-lowering power. Use the Shotlee app to track your current protocol and build baseline data for whatever comes next.

What Is Icosema?

Icosema is Novo Nordisk\'s investigational fixed-ratio combination of insulin icodec (a once-weekly basal insulin) and semaglutide (a GLP-1 receptor agonist). By combining both in a single weekly injection, it aims to simplify diabetes management while providing the metabolic benefits of GLP-1 therapy alongside insulin\'s glucose-lowering power.

Track your current protocol in Shotlee while this science evolves. Having clean historical data means you can compare outcomes with precision if you ever switch medications.

How It Works

🔬

Insulin Icodec

Once-weekly basal insulin. Steady glucose control. Reduces injection burden. Track insulin data in Shotlee

🔬

Semaglutide Component

GLP-1 receptor agonist. Appetite suppression. Weight management benefits. Log weight trends in Shotlee

Combination Advantage

Single weekly injection. Simplified regimen. Dual metabolic action. Monitor both effects in Shotlee

🔬

Why This Matters

Managing both insulin and GLP-1 therapy in a single weekly injection dramatically simplifies treatment for people with Type 2 diabetes. Tracking dose adherence and metabolic markers in Shotlee ensures

Clinical Data

Multiple Phase 3 trials (COMBINE program) are evaluating Icosema in Type 2 diabetes populations.

Side Effects

01

Hypoglycemia (insulin component)

02

GI symptoms (semaglutide component)

03

Injection site reactions

04

Track all side effects in Shotlee

Vital Protocol FAQs

🔬

What is Icosema?

Icosema is a fixed-ratio combination of once-weekly insulin icodec and semaglutide in a single injection. It is designed for people with Type 2 diabetes. Track your insulin and GLP-1 protocols togethe

🔬

Is Icosema approved?

Icosema is still in Phase 3 trials. Use Shotlee to track your current insulin and GLP-1 protocols while awaiting results.

Guide FAQs

Complete guide to Icosema. Icosema is Novo Nordisk

Yes. Shotlee supports tracking Icosema doses, side effects, and health metrics. It is free to use.

References

  1. [1]Clinical TrialWilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002.
  2. [2]Clinical TrialMarso SP et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834-1844.

Track Your Icosema Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

🚀 Use Shotlee for Free