📖Complete GuideUpdated 2026🔬Evidence-Based

Gonadorelin (GnRH) Guide

HPTA Restart & PCT

The complete guide to Gonadorelin (synthetic GnRH). Endocrine mechanism, pulsatile pump vs injection.

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6.2 / 10 mg · Vial
~42 days left · Mar 15
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7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
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GoNAD+orelinRetatrutide
0mg2.7mg5.4mg
18
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122/78
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8.4
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1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
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12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
ACTIVE MEDICATIONS
GoNAD+orelinB12
GONAD+ORELIN
🔥 14
2
days away
Thursday · 7.5mg
Medication Supply
GoNAD+orelin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
GoNAD+orelinRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Hypothalamic-Pituitary Restart Protocols

Gonadorelin is a synthetic decapeptide that is perfectly identical to the naturally occurring human Gonadotropin-Releasing Hormone (GnRH). It is the absolute highest upstream hormone in the male and female reproductive cascade.

In the men\'s health and bodybuilding community, it gained massive popularity during the FDA blackout on compounded HCG. Men use it to aggressively restart the Hypothalamic-Pituitary-Testicular Axis (HPTA) to recover natural testosterone production after suppressive steroid cycles or to maintain testicular volume on TRT.

What is it?: Gonadorelin is a synthetic decapeptide that is perfectly identical to the naturally occurring human Gonadotropin-Releasing Hormone (GnRH). It is the absolute highest upstream hormone in the male and female reproductive cascade. In the men\'s health and bodybuilding community, it gained massive popularity during the FDA blackout on compounded HCG. Men use it to aggressively restart the Hypothalamic-Pituitary-Testicular Axis (HPTA) to recover natural testosterone production after suppressive steroid cycles or to maintain testicular volume on TRT.

02WHAT TO TRACK

Mechanisms of Action

01
🔬
The Upstream Cascade
✓Gonadorelin is injected subcutaneously and travels directly to the anterior pituitary gland.. ✓It instructs the pituitary to manufacture and pulse Luteinizing Hormone (LH) and Follicle-Stimulating Ho
02
🔬
The Pulsatility Requirement
✓The pituitary GnRH receptors are highly sensitive. If they are constantly flooded with Gonadorelin, they will rapidly downregulate and completely shut off, causing chemical castration.. ✓It absolutel
03WHAT TO TRACK

Clinical Dosing & Protocols

01
🔬
Standard SubQ
Injected 2-3 times per week when used alongside TRT to maintain testicular function.
02
🔬
Aggressive PCT Pulse
Used daily or via a motorized micro-pump for severe HPTA suppression.
03
🔬
Warning
Taking massive 1mg doses will actually shut down natural production completely via receptor desensitization.
04WHAT TO TRACK

Vital Protocol FAQs

01
🔬
Is Gonadorelin better than HCG?
HCG (Human Chorionic Gonadotropin) acts downstream—it directly ignores the brain and mimics LH right at the testicle. Gonadorelin acts upstream, forcing the brain (pituitary) to do the work. HCG is ge
02
🔬
Can women use Gonadorelin?
Yes, it is often used in fertility medicine via pulsatile pumps to induce ovulation in women with hypothalamic amenorrhea.
05FAQ

Guide FAQs

The complete guide to Gonadorelin (synthetic GnRH). Endocrine mechanism, pulsatile pump vs injection.

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