Retatrutid vs. Mounjaro
Evolution der Inkretin-Therapie (2026)
Retatrutid fügt dem dualen Mechanismus von Mounjaro eine dritte Komponente (Glucagon) hinzu.
Vergleich der Wirkmechanismen
Retatrutide
- ✓Triple agonist: GIP + GLP-1 + glucagon receptors
- ✓Glucagon component increases energy expenditure and fat oxidation
- ✓~24% weight loss at 48 weeks in phase 2 (12 mg dose)
- ✓Phase 3 trials ongoing — not yet FDA-approved
- ✓Developed by Eli Lilly
Mounjaro
- ✓Dual GIP + GLP-1 receptor agonist — first in class
- ✓GIP agonism enhances insulin sensitivity in adipose tissue
- ✓~21% mean weight loss at 72 weeks (SURMOUNT-1, 15 mg)
- ✓GIP may moderate GI side effects vs GLP-1-only drugs
- ✓Half-life ~5 days — once-weekly injection
Detailed Comparison
| Feature | Retatrutide | Mounjaro |
|---|---|---|
| Mechanism | Triple GIP/GLP-1/glucagon receptor agonist | Dual GIP/GLP-1 receptor agonist |
| Dosing | 1-12 mg SC weekly (phase 2 doses) | 2.5-15 mg SC weekly |
| Administration | Subcutaneous injection weekly | Subcutaneous injection weekly |
| Half-life | ~6 days | ~5 days |
| FDA Status | Not FDA-approved — phase 3 clinical trials | FDA-approved: Mounjaro (T2D), Zepbound (obesity) |
| Key Trial | Jastreboff AM et al. NEJM 2023 — phase 2 obesity trial | Jastreboff AM et al. NEJM 2022 (SURMOUNT-1) — 20.9% weight loss |
| Side Effects | Nausea, diarrhea, vomiting, constipation (similar to other incretins) | Nausea (31%), vomiting, diarrhea, constipation |
Which Should You Choose?
Retatrutide (triple gip/glp-1/glucagon receptor agonist) and Tirzepatide (dual gip/glp-1 receptor agonist) serve different clinical roles despite both being in the Triple incretin agonist space. Retatrutide first triple incretin agonist targeting gip, glp-1, and glucagon receptors. Tirzepatide first-in-class dual gip and glp-1 receptor agonist that activates two incretin pathways for enhanced weight loss and glycemic control vs single agonists.
Whichever you choose, track your protocol in Shotlee to build clean data for dose optimization and outcomes comparison.
Track Both in Shotlee
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Retatrutide vs Mounjaro: Häufig gestellte Fragen
Frühe Daten deuten auf einen noch stärkeren Gewichtsverlust hin, da der Glucagon-Anteil den Stoffwechsel zusätzlich ankurbelt.
Quellen
- [1]Clinical TrialJastreboff AM et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med. 2023;389(6):514-526.
- [2]Clinical TrialJastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). N Engl J Med. 2022;387(3):205-216.
- [3]FDAEli Lilly. Mounjaro (tirzepatide) Prescribing Information. U.S. Food and Drug Administration.
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