Ozempic vs. Mounjaro
Which GLP-1 is Right for You? (2026 Guide)
The battle of the heavyweights: Semaglutide (Ozempic) vs. Tirzepatide (Mounjaro). We break down the science, the results, and the costs to help you verify your choice with your doctor.
| Feature | Ozempic | Mounjaro |
|---|---|---|
| Active Ingredient | Semaglutide | Tirzepatide |
| Mechanism | GLP-1 Agonist | Dual GLP-1 & GIP Agonist |
| Weight Loss (Trials) | ~15% body weight | ~21% body weight |
| FDA Approval | Type 2 Diabetes | Type 2 Diabetes |
| Weight Loss ver. | Wegovy | Zepbound |
| Weekly Injection? | Yes | Yes |
Why Choose Ozempic?
- ✓Proven track record since 2017
- ✓Strong cardiovascular benefits data
- ✓Widely covered by many insurance plans
- ✓Adjustable "click" pens (in some regions)
Why Choose Mounjaro?
- ✓Dual action (GLP-1 + GIP) often more potent
- ✓Higher average weight loss in clinical head-to-heads
- ✓May break plateaus where Ozempic stopped working
- ✓Single-dose auto-injector pens (easy to use)
Common Questions
Can I switch from Ozempic to Mounjaro?
Many patients switch from Ozempic to Mounjaro, especially if they have plateaued. Always consult your doctor for a conversion protocol, as you typically start at a lower dose to assess tolerance.
Which one has fewer side effects?
Studies show comparable side effect profiles (nausea, GI issues). However, some users report feeling better on Mounjaro due to the GIP component, while others tolerate Ozempic better. It is highly individual.
How do I track my doses?
Keeping a consistent log is crucial for both medications to monitor effectiveness and side effects. That's exactly where Shotlee comes in.
Track Your Comparison Journey
Whether you choose Ozempic or Mounjaro, tracking your doses, weight, and side effects is the best way to see what works for your body.
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