📖Complete GuideUpdated 2026🔬Evidence-Based

Bremelanotide (Vyleesi) Guide

FDA-Approved HSDD Treatment

Bremelanotide is an FDA-approved melanocortin receptor agonist for acquired generalized hypoactive sexual desire disorder in premenopausal women. It is not indicated to enhance sexual performance or to treat men.

Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
ACTIVE MEDICATIONS
BremelanotideB12
BREMELANOTIDE
🔥 14
2
days away
Thursday · 7.5mg
Medication Supply
Bremelanotide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
BremelanotideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
ACTIVE MEDICATIONS
BremelanotideB12
BREMELANOTIDE
🔥 14
2
days away
Thursday · 7.5mg
Medication Supply
Bremelanotide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
BremelanotideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Prescription Melanocortin Therapy

Bremelanotide (Vyleesi) is a melanocortin receptor agonist indicated for acquired generalized hypoactive sexual desire disorder in premenopausal women. The FDA label does not support use for men or for sexual performance enhancement.

Track the exact dose, timing, and any adverse effects if you are following a prescribed plan, since nausea, flushing, headache, and injection-site reactions are the most common tolerability issues.

02DEEP DIVE

What Is Bremelanotide (PT-141)?

Bremelanotide is a prescription medication with a specific FDA indication: acquired generalized hypoactive sexual desire disorder in premenopausal women. It is not indicated to enhance sexual performance and should not be described as a general aphrodisiac.

Because it can raise blood pressure transiently and commonly causes nausea, the label recommends careful attention to cardiovascular risk, dose timing, and tolerability.

03MECHANICS

Administration Highlights

1
Indicated only for premenopausal women with acquired generalized HSDD
2
Injected subcutaneously as needed before anticipated sexual activity
3
Do not use more than one dose in 24 hours
4
Do not use more than 8 doses per month
5
Common adverse effects include nausea, flushing, headache, and vomiting
04DEEP DIVE

Dosing Protocol

The labeled dose is 1.75 mg subcutaneously as needed at least 45 minutes before anticipated sexual activity.

Do not exceed one dose within 24 hours or eight doses in a month.

The label advises against use in men and in postmenopausal women.

05WHAT TO TRACK

Side Effects & Safety

01
🔬
Expected Effects
Nausea, flushing, headache, vomiting, and injection-site reactions
02
Skin-Related
Focal hyperpigmentation can occur and may persist in some patients
06WHAT TO TRACK

Key Questions

01
🔬
What is Bremelanotide used for?
It is approved for acquired generalized hypoactive sexual desire disorder in premenopausal women, not for performance enhancement.
02
🔬
What side effects should I watch for?
Nausea, flushing, headache, and hyperpigmentation are the main tolerability issues to monitor.
07FAQ

Guide FAQs

Bremelanotide is a prescription melanocortin receptor agonist approved for acquired generalized hypoactive sexual desire disorder in premenopausal women.

Yes. Shotlee supports tracking Bremelanotide doses, side effects, and health metrics. It is free to use.

Free · Always

Track Your Bremelanotide Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

📚References & sources

Start tracking