Weight loss medication Wegovy is now available in pill form, delivering the same active ingredient, semaglutide, as the weekly injections but as a daily oral dose. This option could improve accessibility and affordability for obesity treatment.
Dr. Drew Payne on Key Differences
The FDA-approved pill contains the same medicine as Wegovy injections, but it requires higher dosages because absorption in the gastrointestinal tract is lower, explained Dr. Drew Payne, D.O., an internist at Texas Tech Health Sciences Center specializing in obesity.
"The ingredient in the pill or the active medicine in the pill is the same as the injection," Payne said. "The only real kind of difference is the medicine isn't absorbed as well in the GI tract so the dosage is quite a bit higher."
Consistent Weight Loss Results
At maximum doses, both the pill and injection versions help patients lose about 15% of their body weight on average, according to Payne. Side effects are also similar between the two forms.
Patient Pam Simpson lost 55 pounds using the injection and called it "one of the best decisions I've ever made." Diane Harlan lost 105 pounds, reducing her blood pressure medication needs, and said, "I think it's a miracle... It was the easiest thing I've ever done."
Significant Cost Savings
The pill version costs much less than injections. Wegovy pricing starts at $149 per month, with the highest doses under $400, compared to over $1,000 monthly for some injection users.
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"The cost will be less because it's less to manufacture," Payne said. "You don't have the auto-injector cost built into it."
Prescription Requirements and Switching
A prescription is still required for the pill. Patients can order it directly from the manufacturer's website with a physician's approval, and local pharmacies will soon stock it.
- Approved for patients age 12 and older
- Current injection users can switch to the pill
- Apps like Shotlee help track daily GLP-1 doses for consistency
"You can switch from an injection to a pill," Payne said. Simpson prefers sticking with injections: "I don't like the idea of taking a pill every day."
The drug does not work for everyone, and rare serious side effects are possible, necessitating doctor monitoring via prescription.