5-Amino-1MQ Tracker
Track the NNMT Inhibitor That Boosts NAD+ and Metabolism
5-Amino-1MQ inhibits NNMT — the enzyme that wastes NAD+ precursors. The result: elevated NAD+, activated SIRT1, and enhanced metabolic rate. Track doses, energy, and body composition response with Shotlee.
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, cell-permeable inhibitor of NNMT (nicotinamide N-methyltransferase). NNMT is highly expressed in adipose tissue and the liver, where it consumes methionine and nicotinamide to produce 1-methylnicotinamide — effectively wasting NAD+ precursors and reducing the metabolic activity of fat cells.
By inhibiting NNMT, 5-Amino-1MQ prevents this depletion pathway, raising intracellular NAD+ levels. Elevated NAD+ activates sirtuins (particularly SIRT1), which in turn promotes mitochondrial biogenesis, fatty acid oxidation, and energy expenditure. In mouse studies, NNMT inhibition reduced fat mass while preserving lean mass without caloric restriction.
Oral small molecule — no injection required. Research compound not approved for human use. The guide for 5-Amino-1MQ covers the science in depth; this tracker helps you log your systematic personal experiment.
FAQ
What is 5-Amino-1MQ?
An NNMT inhibitor that preserves NAD+ precursors, raising intracellular NAD+, activating SIRT1, and increasing metabolic rate. Mouse studies show fat mass reduction without caloric restriction.
How do I take it?
Oral capsule or powder, 50–150mg/day based on mouse dose translations. No injection required. Research compound — physician guidance recommended.
How do I track it on Shotlee?
Log daily oral dose, track energy, body weight, and any metabolic markers. Perfect for n=1 experimentation where tracking consistency reveals your personal response curve.